The formation of a new microvasculature is essential for the long-term survival and function
of the islet graft. In this study we examined endothelium of isolated pancreatic islets by …

Lack of rapid revascularization and inflammatory attacks at the site of transplantation
contribute to impaired islet engraftment and suboptimal metabolic control after clinical islet …

All pancreatic cell populations arise from the standard gut endoderm layer in developing
embryos, requiring a regulatory gene network to originate and maintain endocrine lineages …

Background. Insufficient revascularization of transplanted islets may result in chronic
hypoxia and loss of islet function. This study investigated whether simple culture of islets …

As one of the key nutrient sensors, insulin signaling plays an important role in integrating
environmental energy cues with organism growth. In adult organisms, relative insufficiency …

The extracellular matrix (ECM) critically affects β cell functions via integrin activation. But
whether these ECM actions drive the spatial organization of β cells, as they do in epithelial …

The targeted disruption of the two nonallelic insulin genes in mouse was reported previously
to result in intrauterine growth retardation, severe diabetes immediately after suckling, and …

Ex vivo gene therapy approaches can improve the outcome of islet transplantation for
treating type I diabetes. We have recently shown improvement in islet survival and function …

Islet-cell hormone release is modulated by signals from endothelial and endocrine cells
within the islet. However, models of intraislet vascularization and paracrine cell signaling are …

Aims/hypothesis Islet vascular fibrosis may play an important role in the progression of type
2 diabetes, but there are no mouse models allowing detailed mechanistic studies to …