Islet-cell hormone release is modulated by signals from endothelial and endocrine cells
within the islet. However, models of intraislet vascularization and paracrine cell signaling are …

Aims/hypothesis Islet vascular fibrosis may play an important role in the progression of type
2 diabetes, but there are no mouse models allowing detailed mechanistic studies to …

Pancreatic islet transplantation still represents a promising therapeutic strategy for curative
treatment of type 1 diabetes mellitus. However, a limited number of organ donors and …

Maintenance of pancreatic β-cell mass depends on extracellular stimuli that promote
survival and proliferation. In the islet, these stimuli come from the β-cell microenvironment …

Background In both humans and rodents, glucose homeostasis is controlled by micro-
organs called islets of Langerhans composed of beta cells, associated with other endocrine …

Purpose Ex vivo gene therapy approaches can improve the outcome of islet transplantation
for treating type I diabetes. We have previously shown the improvement in islet function and …

Diabetes, particularly type 1 diabetes, results from the lack of pancreatic β-cells. β-cell
replenishment can functionally reverse diabetes, but two critical challenges face the field: 1 …

Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor, which also stimulates
insulin release. The aim of the present study was to evaluate whether exogenously …

Islet microvasculature provides key architectural and functional roles, yet the morphological
features of islets from patients with type 1 diabetes are poorly defined. We examined islet …

Lineage tracing studies have revealed that transcription factors play a cardinal role in
pancreatic development, differentiation and function. Three transitions define pancreatic …