Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

Peripheral arterial disease is a major complication of diabetes. The ability to promote
therapeutic angiogenesis may be limited in diabetes. Type 2 diabetes was induced by high …

Background. Pancreatic islet transplantation has been validated as a treatment for type 1
diabetes. However, a high number of islets is required to establish euglycemia …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …

Development of the endocrine compartment of the pancreas, as represented by the islets of
Langerhans, occurs through a series of highly regulated events encompassing branching of …

Diabetes mellitus is commonly considered as a disease of a scant β-cell mass that fails to
respond adequately to the functional demand. Tyrosine kinases may play a role for β-cell …

A small number of cells in the adult pancreas are endocrine cells. They are arranged in
clusters called islets of Langerhans. The islets make insulin, glucagon, and other endocrine …

Given the inherent therapeutic potential of the morphogenetic plasticity of adult human islets,
the identification of factors controlling their cellular differentiation is of interest. The …

Neovascularization may be necessary for better and longer function of transplanted islets.
Vascular endothelial growth factor (VEGF) is known to be one of the most important factors …

Purpose. Islet transplantation is limited by islet graft failure because of poor
revascularization, host immune rejection, and nonspecific inflammatory response. Human …