Conventional anticancer therapies such as radiotherapy and chemotherapies are
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …

Abstract NF-E2-related factor 2 (NRF2) is a master regulator of redox homeostasis and
provides cellular protection against oxidants and electrophiles by inducing the expression of …

The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …

A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the
Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many …

The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …

Background Nrf2 regulates oxidative stress, which is essential for cellular function.
Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & …

Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …