[HTML][HTML] Controversy about pharmacological modulation of Nrf2 for cancer therapy
Conventional anticancer therapies such as radiotherapy and chemotherapies are
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …
Nrf2 in cancers: A double‐edged sword
S Wu, H Lu, Y Bai - Cancer medicine, 2019 - Wiley Online Library
Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
Potential applications of NRF2 inhibitors in cancer therapy
E Panieri, L Saso - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
The Nrf2-Keap1-ARE signaling pathway: the regulation and dual function of Nrf2 in cancer
DD Zhang - Antioxidants & redox signaling, 2010 - liebertpub.com
The NF-E2-related factor-2 (Nrf2) is a transcription factor that is ubiquitously expressed at
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
low levels in all human organs. As Nrf2 regulates a major cellular defense mechanism, tight …
Molecular mechanisms and systemic targeting of NRF2 dysregulation in cancer
JS Kang, LB Nam, OK Yoo, YS Keum - Biochemical Pharmacology, 2020 - Elsevier
Abstract NF-E2-related factor 2 (NRF2) is a master regulator of redox homeostasis and
provides cellular protection against oxidants and electrophiles by inducing the expression of …
provides cellular protection against oxidants and electrophiles by inducing the expression of …
Potential applications of NRF2 modulators in cancer therapy
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: A review
A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the
Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many …
Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many …
[HTML][HTML] Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy
The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …
Dual role of Nrf2 in cancer: Molecular mechanisms, cellular functions and therapeutic interventions
M Poornashree, H Kumar, R Ajmeer, R Jain… - Molecular Biology …, 2023 - Springer
Background Nrf2 regulates oxidative stress, which is essential for cellular function.
Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & …
Fundamental initiation of Nrf2 in many malignancies increases prosurvival genes & …
Oxidative stress and cancer: the role of Nrf2
S Sajadimajd, M Khazaei - Current cancer drug targets, 2018 - ingentaconnect.com
Oxidative stress due to imbalance between ROS production and detoxification plays a
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …
pivotal role in determining cell fate. In response to the excessive ROS, apoptotic signaling …
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