Adaptive immunity in neurodegenerative and neuropsychological disorders

R Lee Mosley - Journal of neuroimmune pharmacology, 2015 - Springer
Neurodegenerative and neuropsychological disorders are becoming a greater proportion of
the global disease burden; however the pathogenic mechanisms by which these disorders …

[HTML][HTML] Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

KM Anderson, KE Olson, KA Estes, K Flanagan… - Translational …, 2014 - Springer
Inappropriate T cell responses in the central nervous system (CNS) affect the pathogenesis
of a broad range of neuroinflammatory and neurodegenerative disorders that include, but …

Inflammation in neurodegenerative diseases–an update

S Amor, LAN Peferoen, DYS Vogel, M Breur… - …, 2014 - Wiley Online Library
Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous
system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal …

[HTML][HTML] CNS inflammation and neurodegeneration

T Chitnis, HL Weiner - The Journal of clinical investigation, 2017 - Am Soc Clin Investig
There is an increasing recognition that inflammation plays a critical role in
neurodegenerative diseases of the CNS, including Alzheimer's disease, amyotrophic lateral …

[HTML][HTML] Innate immunity and neurodegenerative diseases–triggers from self and non-self

J Hulse, A Bachstetter, S Paul… - Frontiers in Molecular …, 2023 - frontiersin.org
While innate immune responses are typically short-lived, resolving upon clearance of the
inciting pathogen or damage-associated molecular pattern, unresolved innate immune …

[引用][C] Innate and acquired immunity in neurodegenerative disorders

HE Gendelman, DG Folks - Journal of leukocyte biology, 1999 - academic.oup.com
We are pleased to publish in one issue papers linking brain immune function with
neurodegeneration. Together, these works uncover important but common neuroimmune …

A perspective on roles played by innate and adaptive immunity in the pathobiology of neurodegenerative disorders

HE Gendelman, RL Mosley - Journal of Neuroimmune Pharmacology, 2015 - Springer
Aberrant innate and adaptive immune responses are neurodegenerative disease effectors.
Disease is heralded by a generalized, but subtle immune activation orchestrated by the …

[HTML][HTML] Immunological aspects of central neurodegeneration

M Niso-Santano, JM Fuentes, L Galluzzi - Cell Discovery, 2024 - nature.com
The etiology of various neurodegenerative disorders that mainly affect the central nervous
system including (but not limited to) Alzheimer's disease, Parkinson's disease and …

Inflammation in CNS neurodegenerative diseases

J Stephenson, E Nutma, P van der Valk, S Amor - Immunology, 2018 - Wiley Online Library
Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: boosting autoimmunity to fight-off chronic neuroinflammation

M Schwartz, K Baruch - Journal of autoimmunity, 2014 - Elsevier
Immune cell infiltration to the brain's territory was considered for decades to reflect a
pathological process in which immune cells attack the central nervous system (CNS); such a …