The landscape of human STR variation

T Willems, M Gymrek, G Highnam, D Mittelman… - Genome …, 2014 - genome.cshlp.org
Short tandem repeats are among the most polymorphic loci in the human genome. These
loci play a role in the etiology of a range of genetic diseases and have been frequently …

Genome-wide profiling of heritable and de novo STR variations

T Willems, D Zielinski, J Yuan, A Gordon, M Gymrek… - Nature …, 2017 - nature.com
Short tandem repeats (STRs) are highly variable elements that play a pivotal role in multiple
genetic diseases, population genetics applications, and forensic casework. However, it has …

Characterization of genome-wide STR variation in 6487 human genomes

Y Shi, Y Niu, P Zhang, H Luo, S Liu, S Zhang… - Nature …, 2023 - nature.com
Short tandem repeats (STRs) are abundant and highly mutagenic in the human genome.
Many STR loci have been associated with a range of human genetic disorders. However …

Sequencing and characterizing short tandem repeats in the human genome

HA Tanudisastro, IW Deveson, H Dashnow… - Nature Reviews …, 2024 - nature.com
Short tandem repeats (STRs) are highly polymorphic sequences throughout the human
genome that are composed of repeated copies of a 1–6-bp motif. Over 1 million variable …

STRSeq: A catalog of sequence diversity at human identification Short Tandem Repeat loci

KB Gettings, LA Borsuk, D Ballard, M Bodner… - Forensic Science …, 2017 - Elsevier
Abstract The STR Sequencing Project (STRSeq) was initiated to facilitate the description of
sequence-based alleles at the Short Tandem Repeat (STR) loci targeted in human …

Profiling of short-tandem-repeat disease alleles in 12,632 human whole genomes

H Tang, EF Kirkness, C Lippert, WH Biggs… - The American Journal of …, 2017 - cell.com
Short tandem repeats (STRs) are hyper-mutable sequences in the human genome. They are
often used in forensics and population genetics and are also the underlying cause of many …

Population-scale sequencing data enable precise estimates of Y-STR mutation rates

T Willems, M Gymrek, GD Poznik, C Tyler-Smith… - The American Journal of …, 2016 - cell.com
Short tandem repeats (STRs) are mutation-prone loci that span nearly 1% of the human
genome. Previous studies have estimated the mutation rates of highly polymorphic STRs by …

Accurate typing of short tandem repeats from genome-wide sequencing data and its applications

A Fungtammasan, G Ananda, SE Hile, MSW Su… - Genome …, 2015 - genome.cshlp.org
Short tandem repeats (STRs) are implicated in dozens of human genetic diseases and
contribute significantly to genome variation and instability. Yet profiling STRs from short-read …

A genomic view of short tandem repeats

M Gymrek - Current opinion in genetics & development, 2017 - Elsevier
Short tandem repeats (STRs) are some of the fastest mutating loci in the genome. Tools for
accurately profiling STRs from high-throughput sequencing data have enabled genome …

lobSTR: a short tandem repeat profiler for personal genomes

M Gymrek, D Golan, S Rosset, Y Erlich - Genome research, 2012 - genome.cshlp.org
Short tandem repeats (STRs) have a wide range of applications, including medical genetics,
forensics, and genetic genealogy. High-throughput sequencing (HTS) has the potential to …