The calcineurin pathway is a critical signal transduction pathway in fungi that mediates
growth, morphology, stress responses, and pathogenicity. The importance of the calcineurin …

Background Calcineurin, a serine/threonine-specific protein phosphatase, plays an
important role in the control of cell morphology and virulence in fungi. Calcineurin regulates …

Ca2+, as a second messenger in cells, enables organisms to adapt to different
environmental stresses by rapidly sensing and responding to external stimuli. In recent …

Calcineurin is implicated in a myriad of human diseases as well as homeostasis and
virulence in several major human pathogenic microorganisms. The fungus Aspergillus …

The protein phosphatase calcineurin is an important mediator connecting calcium‐
dependent signalling to various cellular responses in multiple organisms. In fungi …

The fungus Aspergillus fumigatus is a leading infectious killer in immunocompromised
patients. Calcineurin, a calmodulin (CaM)-dependent protein phosphatase comprised of …

Aspergillus fumigatus causes invasive aspergillosis, the most common life-threatening
fungal disease of immuno-compromised humans. The treatment of disseminated infections …

Calcineurin is a heterodimeric protein phosphatase complex composed of catalytic (CnaA)
and regulatory (CnaB) subunits and plays diverse roles in regulating fungal stress …

Calcineurin signaling plays diverse roles in fungi in regulating stress responses,
morphogenesis and pathogenesis. Although calcineurin signaling is conserved among …

The echinocandin antifungal drug caspofungin at high concentrations reverses the growth
inhibition of Aspergillus fumigatus, a phenomenon known as the “paradoxical effect,” which …