Rationale: Characterization of bacterial populations in infectious respiratory diseases will
provide improved understanding of the relationship between the lung microbiota, disease …

Rationale: Although airway microbiota composition correlates with clinical measures in non–
cystic fibrosis bronchiectasis, these data are unlikely to provide useful prognostic information …

Background Infection is a key component of bronchiectasis pathophysiology.
Characterisation of the microbiome offers a higher degree of sensitivity and resolution than …

Rationale: Emerging data support the existence of a microbial “gut-lung” axis that remains
unexplored in bronchiectasis. Methods: Prospective and concurrent sampling of gut (stool) …

Background Bronchiectasis is accompanied by chronic bronchial infection that may drive
disease progression. However, the evidence base for antibiotic therapy is limited. DNA …

Background Recent studies suggest that lung microbiome dysbiosis, the disease associated
disruption of the lung microbial community, might play a key role in chronic obstructive …

Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are
limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the …

Rationale Despite the potentially important roles for infection in adult non-cystic fibrosis (CF)
bronchiectasis disease progression, the bacterial species present in the lower airways of …

Culture of bacteria from bronchial secretions in respiratory patients has low sensitivity and
does not allow for complete assessment of microbial diversity across different bronchial …

Background Molecular methods based on phylogenetic differences in the 16S rRNA gene
are able to characterise the microbiota of the respiratory tract in health and disease …