Since the initial discovery of the oncogenic activity of WNT ligands our understanding of the
complex roles for WNT signaling pathways in lung cancers has increased substantially. In …

Background: Wnt2 is overexpressed and able to promote tumorigenesis in many types of
cancer. However, its expression and role in lung cancer has not been well clarified yet. In …

OBJECTIVE: Aberrant activation of (Wingless and mouse homolog Int-1) Wnt/β-catenin
signaling pathways closely involved in the occurrence and progression of several types of …

The Wnt pathway plays an important role in development and in regulating adult stem cell
systems. A variety of cellular processes is mediated by Wnt signaling, which includes …

Lung cancer has the highest mortality rate compared to any other cancer worldwide, and
cigarette smoking is one of the major etiological factors. How cigarette smoke (CS) induces …

A recent study indicated that high Wnt5a expression is associated with poor prognosis in
non-small-cell lung cancer (NSCLC) patients; however, the underlying mechanism was not …

Lung cancer is the most common cause of cancer mortality worldwide. Non-small-cell lung
carcinomas (NSCLCs), which represent around 80% of lung tumors, exhibit poor prognosis …

BACKGROUND: The Wnt gene family is involved in embryogenesis and tumourigenesis. We
investigated the clinical significance of Wnt1 expression in non-small cell lung cancer …

Wnt/β-catenin signaling is a critical pathway that influences development and therapeutic
response of non-small cell lung cancer (NSCLC). In recent years, many Wnt regulators …

The majority of lung cancers (LC) belong to the non-small cell lung carcinoma (NSCLC)
type. The two main NSCLC sub-types, namely adenocarcinoma (AC) and squamous cell …