Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones

AS Kauffman - Journal of neuroendocrinology, 2010 - Wiley Online Library
The brains of males and females differ anatomically and physiologically, including sex
differences in neurone size or number, synapse morphology and specific patterns of gene …

Sex steroids and the control of the Kiss1 system: developmental roles and major regulatory actions

D García‐Galiano, L Pinilla… - Journal of …, 2012 - Wiley Online Library
Kisspeptins, encoded by the Kiss1 gene, and their canonical receptor, GPR54 (also termed
Kiss1R), are unanimously recognised as essential regulators of puberty onset and …

Developmental GnRH Signaling Is Not Required for Sexual Differentiation of Kisspeptin Neurons but Is Needed for Maximal Kiss1 Gene Expression in Adult Females

J Kim, KP Tolson, S Dhamija, AS Kauffman - Endocrinology, 2013 - academic.oup.com
Kisspeptin, encoded by Kiss1, stimulates reproduction. In rodents, one Kiss1 population
resides in the hypothalamic anterior ventral periventricular nucleus and neighboring rostral …

The two kisspeptin neuronal populations are differentially organized and activated by estradiol in mice

O Brock, J Bakker - Endocrinology, 2013 - academic.oup.com
In rodents, kisspeptin-expressing neurons are localized in 2 hypothalamic brain nuclei
(anteroventral periventricular nucleus/periventricular nucleus continuum [AVPv/PeN] and …

Arcuate and preoptic kisspeptin neurons exhibit differential projections to hypothalamic nuclei and exert opposite postsynaptic effects on hypothalamic paraventricular …

TL Stincic, J Qiu, AM Connors, MJ Kelly… - eneuro, 2021 - eneuro.org
Kisspeptin (Kiss1) neurons provide indispensable excitatory input to gonadotropin-releasing
hormone (GnRH) neurons, which is important for the coordinated release of gonadotropins …

Estrogen Stimulation of Kiss1 Expression in the Medial Amygdala Involves Estrogen Receptor-α But Not Estrogen Receptor-β

SBZ Stephens, N Chahal, N Munaganuru… - …, 2016 - academic.oup.com
The neuropeptide kisspeptin, encoded by Kiss1, regulates reproduction by stimulating
GnRH secretion. Neurons synthesizing kisspeptin are predominantly located in the …

[HTML][HTML] Reproductive hormone-dependent and-independent contributions to developmental changes in kisspeptin in GnRH-deficient hypogonadal mice

JC Gill, O Wang, S Kakar, E Martinelli, RS Carroll… - PLoS …, 2010 - journals.plos.org
Kisspeptin is a potent activator of GnRH-induced gonadotropin secretion and is a proposed
central regulator of pubertal onset. In mice, there is a neuroanatomical separation of two …

Specialized subpopulations of kisspeptin neurons communicate with GnRH neurons in female mice

D Kumar, M Candlish, V Periasamy, N Avcu… - …, 2015 - academic.oup.com
The neuropeptide kisspeptin is a potent stimulator of GnRH neurons and has been
implicated as a major regulator of the hypothalamus-pituitary-gonadal axis. There are mainly …

Maturation of kisspeptinergic neurons coincides with puberty onset in male rats

AH Bentsen, L Ansel, V Simonneaux, M Tena-Sempere… - Peptides, 2010 - Elsevier
Kisspeptins, derived from the Kiss1 gene play a central role in activation of the hypothalamo-
pituitary gonadal (HPG) axis via stimulation of GnRH neurons. Both Kiss1 and Kiss1R …

Sexual Differentiation of Kiss1 Gene Expression in the Brain of the Rat

AS Kauffman, ML Gottsch, J Roa, AC Byquist… - …, 2007 - academic.oup.com
The Kiss1 gene codes for kisspeptins, which have been implicated in the neuroendocrine
regulation of reproduction. In the brain, Kiss1 mRNA-expressing neurons are located in the …