Shedding light on the mechanisms underlying the environmental regulation of secondary metabolite ganoderic acid in Ganoderma lucidum using physiological and …

A Ren, L Shi, J Zhu, H Yu, A Jiang, H Zheng… - Fungal genetics and …, 2019 - Elsevier
The secondary metabolites of fungi are often produced at very low concentrations, and until
recently the regulatory mechanisms of secondary metabolite biosynthesis have been …

Advances in the biosynthesis, diversification, and hyperproduction of ganoderic acids in Ganoderma lucidum

P Bondzie-Quaye, MS Swallah, A Acheampong… - Mycological …, 2023 - Springer
Ganoderic acids (GA) are one of the important secondary metabolites acquired from
Ganoderma lucidum (G. lucidum) with a wide range of pharmacological activities and …

Effect of solid-medium coupled with reactive oxygen species on ganoderic acid biosynthesis and MAP kinase phosphorylation in Ganoderma lucidum

BJ You, WT Chang, KR Chung, YH Kuo… - Food research …, 2012 - Elsevier
Ganoderma lucidum is used as a functional food and medicinal mushroom in Asia.
Biosynthesis of its active ingredients, the ganoderic acids (GAs), together with signal …

[HTML][HTML] Transcriptome and metabolome analyses reveal transcription factors regulating ganoderic acid biosynthesis in Ganoderma lucidum development

L Meng, R Zhou, J Lin, X Zang, Q Wang… - Frontiers in …, 2022 - frontiersin.org
Ganoderma lucidum is an important medicinal fungus in Asian countries. Ganoderic acid
(GA) is the major variety of bioactive and medicative components in G. lucidum. Biosynthesis …

[HTML][HTML] Profiling and Quantifying Differential Gene Transcription Provide Insights into Ganoderic Acid Biosynthesis in Ganoderma lucidum in Response to Methyl …

A Ren, MJ Li, L Shi, DS Mu, AL Jiang, Q Han… - PloS one, 2013 - journals.plos.org
Ganoderma lucidum is a mushroom with traditional medicinal properties that has been
widely used in China and other countries in Eastern Asia. Ganoderic acids (GA) produced …

[HTML][HTML] A Novel Approach to Enhancing Ganoderic Acid Production by Ganoderma lucidum Using Apoptosis Induction

BJ You, MH Lee, N Tien, MS Lee, HC Hsieh, LH Tseng… - PloS one, 2013 - journals.plos.org
Ganoderma lucidum is one of most widely used herbal medicine and functional food in Asia,
and ganoderic acids (GAs) are its active ingredients. Regulation of GA biosynthesis and …

[HTML][HTML] Integrated proteomics and metabolomics analysis provides insights into ganoderic acid biosynthesis in response to methyl jasmonate in Ganoderma lucidum

AL Jiang, YN Liu, R Liu, A Ren, HY Ma, LB Shu… - International Journal of …, 2019 - mdpi.com
Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously
reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of …

Cross talk between nitric oxide and calcium-calmodulin regulates ganoderic acid biosynthesis in Ganoderma lucidum under heat stress

R Liu, L Shi, T Zhu, T Yang, A Ren, J Zhu… - Applied and …, 2018 - Am Soc Microbiol
We previously reported that high temperature impacts ganoderic acid (GA) biosynthesis in
Ganoderma lucidum via Ca2+. Therefore, to further understand the signal-regulating …

Current progress in the study on biosynthesis and regulation of ganoderic acids

L Shi, A Ren, D Mu, M Zhao - Applied microbiology and biotechnology, 2010 - Springer
Ganoderic acids (GAs) isolated from Ganoderma lucidum, which have shown remarkable
pharmacological activities and a variety of therapeutic effects on a number of human …

Transcriptome dynamics and metabolite analysis revealed the candidate genes and regulatory mechanism of ganoderic acid biosynthesis during liquid superficial …

Q Wang, M Xu, L Zhao, F Wang, Y Li… - Microbial …, 2021 - Wiley Online Library
Ganoderic acid (GA), an important secondary metabolite of Ganoderma lucidum, exhibited
many significant pharmacological activities. In this study, the biosynthetic mechanism of GAs …