Functions of reactive oxygen species in apoptosis and ganoderic acid biosynthesis in Ganoderma lucidum

J Zhu, F Wu, S Yue, C Chen, S Song… - FEMS Microbiology …, 2019 - academic.oup.com
Ganoderma lucidum is a medicinal fungus that is widely used in traditional medicine. Fungal
PacC is recognized as an important transcription factor that functions during adaptation to …

The mitogen-activated protein kinase GlSlt2 regulates fungal growth, fruiting body development, cell wall integrity, oxidative stress and ganoderic acid biosynthesis in …

G Zhang, Z Sun, A Ren, L Shi, D Shi, X Li… - Fungal Genetics and …, 2017 - Elsevier
The mitogen-activated protein kinases (MAPKs) are crucial signaling instruments in
eukaryotes that play key roles in regulating fungal growth, development, and secondary …

Induction of ganoderic acid biosynthesis by Mn2+ in static liquid cultivation of Ganoderma lucidum

YN Xu, XX Xia, JJ Zhong - Biotechnology and bioengineering, 2014 - Wiley Online Library
Metal ions affect cell physiology and metabolism significantly, but the role of Mn2+ in the
secondary metabolism of mushrooms is yet unclear. In static liquid cultivation of Ganoderma …

Biosynthesis of a novel ganoderic acid by expressing CYP genes from Ganoderma lucidum in Saccharomyces cerevisiae

WF Wang, H Xiao, JJ Zhong - Applied Microbiology and Biotechnology, 2022 - Springer
Ganoderic acids (GAs), a group of highly oxygenated lanostane-type triterpenoids from the
traditional Chinese medicinal mushroom Ganoderma lucidum, possessed significant …

GlMPC activated by GCN4 regulates secondary metabolism under nitrogen limitation conditions in Ganoderma lucidum

Z Wang, J Chen, J Ding, J Han, L Shi - Mbio, 2023 - Am Soc Microbiol
Fungi actively alter their metabolic and synthetic pathways to cope with changing
environmental conditions. The mitochondrial pyruvate carrier (MPC) plays a vital role in …

Genome of Ganoderma Species Provides Insights Into the Evolution, Conifers Substrate Utilization, and Terpene Synthesis for Ganoderma tsugae

N Jiang, S Hu, B Peng, Z Li, X Yuan, S Xiao… - Frontiers in …, 2021 - frontiersin.org
Ganoderma tsugae is an endemic medicinal mushroom in Northeast China, providing
important source of pharmaceutical product. Comparing with other Ganoderma species, wild …

Induced effect of Na+ on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction

YN Xu, XX Xia, JJ Zhong - Biotechnology and Bioengineering, 2013 - Wiley Online Library
Abstract Na+/Ca2+ exchange is important to cell physiology and metabolism, but its role in
the secondary metabolite biosynthesis by fungi is yet unclear. In this work, in static liquid …

Autotoxicity of Endogenous Organic Acid Stress in Two Ganoderma lucidum Cultivars

P Zou, Y Guo, S Ding, Z Song, H Cui, Y Zhang, Z Zhang… - Molecules, 2022 - mdpi.com
Ganoderma lucidum has been used as a rare medical mushroom for centuries in China, due
to its health-promoting properties. Successive cropping obstacles are common in the …

Impacts of calcium signal transduction on the fermentation production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum

YN Xu, JJ Zhong - Biotechnology advances, 2012 - Elsevier
Recently signal transduction engineering of secondary metabolism is receiving great
interest as a powerful tool towards efficient production of valuable secondary metabolites …

Improved ganoderic acids production in Ganoderma lucidum by wood decaying components

Y Hu, S Ahmed, J Li, B Luo, Z Gao, Q Zhang, X Li… - Scientific reports, 2017 - nature.com
Ganoderma lucidum is a legendary Traditional Chinese Medicine (TCM) over a few
thousands of years and one kind of its major active components are Ganoderic acids (GAs) …