Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

SM Rothman, N Herdener, KA Frankola, MR Mughal… - Brain research, 2013 - Elsevier
Age-associated dysregulation of sleep can be worsened by Alzheimer′ s disease (AD). AD
and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction …

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice

GC Kincheski, IS Valentim, JR Clarke… - Brain, behavior, and …, 2017 - Elsevier
It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a
bidirectional relationship. AD patients exhibit sleep problems and alterations in the …

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

A Di Meco, YB Joshi, D Praticò - Neurobiology of aging, 2014 - Elsevier
Several studies have highlighted the frequency of sleep disturbances in Alzheimer's disease
(AD). However, whether they are secondary to the disease or per se increase its risk …

Sleep deprivation accelerates the progression of Alzheimer's disease by influencing Aβ-related metabolism

L Chen, J Huang, L Yang, XA Zeng, Y Zhang… - Neuroscience …, 2017 - Elsevier
Sleep disorders have previously been connected with the neurodegenerative pathology of
Alzheimer's disease (AD) due to the aggregation of β-amyloid (Aβ) peptides and tau …

Chronic fragmentation of the daily sleep-wake rhythm increases amyloid-beta levels and neuroinflammation in the 3xTg-AD mouse model of Alzheimer's disease

MJ Duncan, LE Guerriero, K Kohler, LE Beechem… - Neuroscience, 2022 - Elsevier
Fragmentation of the daily sleep-wake rhythm with increased nighttime awakenings and
more daytime naps is correlated with the risk of development of Alzheimer's disease (AD) …

Sleep and hippocampal neurogenesis: implications for Alzheimer's disease

BA Kent, RE Mistlberger - Frontiers in neuroendocrinology, 2017 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and currently there are no
effective disease-modifying treatments available. Hallmark symptoms of AD include …

[HTML][HTML] Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease

S Dissel, M Klose, J Donlea, L Cao, D English… - Neurobiology of sleep …, 2017 - Elsevier
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's
disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein …

Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE 1‐Antisense Activation

HY Zhao, HJ Wu, JL He, JH Zhuang… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims To clarify the correlation between chronic sleep restriction (CSR) and sporadic
Alzheimer disease (AD), we determined in wild‐type mice the impact of CSR, on cognitive …

Experimental sleep deprivation as a tool to test memory deficits in rodents

V Colavito, PF Fabene, G Grassi-Zucconi… - Frontiers in systems …, 2013 - frontiersin.org
Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and
mice) are here reviewed. The vast majority of these studies have been aimed at …

Late-in-life neurodegeneration after chronic sleep loss in young adult mice

JE Owen, Y Zhu, P Fenik, G Zhan, P Bell, C Liu… - Sleep, 2021 - academic.oup.com
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …