Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease
SM Rothman, N Herdener, KA Frankola, MR Mughal… - Brain research, 2013 - Elsevier
Age-associated dysregulation of sleep can be worsened by Alzheimer′ s disease (AD). AD
and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction …
and sleep restriction both impair cognition, yet it is unknown if mild chronic sleep restriction …
Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice
GC Kincheski, IS Valentim, JR Clarke… - Brain, behavior, and …, 2017 - Elsevier
It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a
bidirectional relationship. AD patients exhibit sleep problems and alterations in the …
bidirectional relationship. AD patients exhibit sleep problems and alterations in the …
Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles
A Di Meco, YB Joshi, D Praticò - Neurobiology of aging, 2014 - Elsevier
Several studies have highlighted the frequency of sleep disturbances in Alzheimer's disease
(AD). However, whether they are secondary to the disease or per se increase its risk …
(AD). However, whether they are secondary to the disease or per se increase its risk …
Sleep deprivation accelerates the progression of Alzheimer's disease by influencing Aβ-related metabolism
L Chen, J Huang, L Yang, XA Zeng, Y Zhang… - Neuroscience …, 2017 - Elsevier
Sleep disorders have previously been connected with the neurodegenerative pathology of
Alzheimer's disease (AD) due to the aggregation of β-amyloid (Aβ) peptides and tau …
Alzheimer's disease (AD) due to the aggregation of β-amyloid (Aβ) peptides and tau …
Chronic fragmentation of the daily sleep-wake rhythm increases amyloid-beta levels and neuroinflammation in the 3xTg-AD mouse model of Alzheimer's disease
MJ Duncan, LE Guerriero, K Kohler, LE Beechem… - Neuroscience, 2022 - Elsevier
Fragmentation of the daily sleep-wake rhythm with increased nighttime awakenings and
more daytime naps is correlated with the risk of development of Alzheimer's disease (AD) …
more daytime naps is correlated with the risk of development of Alzheimer's disease (AD) …
Sleep and hippocampal neurogenesis: implications for Alzheimer's disease
BA Kent, RE Mistlberger - Frontiers in neuroendocrinology, 2017 - Elsevier
Alzheimer's disease (AD) is the most common cause of dementia and currently there are no
effective disease-modifying treatments available. Hallmark symptoms of AD include …
effective disease-modifying treatments available. Hallmark symptoms of AD include …
[HTML][HTML] Enhanced sleep reverses memory deficits and underlying pathology in Drosophila models of Alzheimer's disease
To test the hypothesis that sleep can reverse cognitive impairment during Alzheimer's
disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein …
disease, we enhanced sleep in flies either co-expressing human amyloid precursor protein …
Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE 1‐Antisense Activation
HY Zhao, HJ Wu, JL He, JH Zhuang… - CNS neuroscience & …, 2017 - Wiley Online Library
Aims To clarify the correlation between chronic sleep restriction (CSR) and sporadic
Alzheimer disease (AD), we determined in wild‐type mice the impact of CSR, on cognitive …
Alzheimer disease (AD), we determined in wild‐type mice the impact of CSR, on cognitive …
Experimental sleep deprivation as a tool to test memory deficits in rodents
V Colavito, PF Fabene, G Grassi-Zucconi… - Frontiers in systems …, 2013 - frontiersin.org
Paradigms of sleep deprivation (SD) and memory testing in rodents (laboratory rats and
mice) are here reviewed. The vast majority of these studies have been aimed at …
mice) are here reviewed. The vast majority of these studies have been aimed at …
Late-in-life neurodegeneration after chronic sleep loss in young adult mice
JE Owen, Y Zhu, P Fenik, G Zhan, P Bell, C Liu… - Sleep, 2021 - academic.oup.com
Chronic short sleep (CSS) is prevalent in modern societies and has been proposed as a risk
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
factor for Alzheimer's disease (AD). In support, short-term sleep loss acutely increases levels …
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