Stem cell factor (SCF) activates a variety of signals associated with stimulation of
proliferation, differentiation, migration, and survival in melanocytes. However, the molecular …

We previously reported that activation of mitogen-activated protein kinase (MAPK) is
involved in the mitogenic stimulation of normal human melanocytes (NHMC) by endothelin-1 …

During development, the interaction of stem cell factor (SCF) with its receptor, KIT, is critical
for the survival of melanocytes. Limited in vivo human studies have suggested a possible …

Stem cell factor is a growth factor for normal human melanocytes, that acts through the
tyrosine kinase receptor c‐kit. We have previously demonstrated that stem cell factor …

The signaling of stem cell factor (SCF) and its receptor KIT (membrane-bound KIT; m-KIT)
plays an important role in melanocyte development, survival, proliferation, and …

Stem cell factor (SCF) and its receptor, KIT, are essential to the migration and differentiation
of melanocytes during embryogenesis. We previously demonstrated that apoptosis is …

Melanocytes are derived from neural crest and migrate along the dorsolateral pathway to
colonize the final destination in the skin. Stem cell factor and its receptor c-kit were identified …

Stem cell factor (SCF) is hypothesized to play a critical role in the migration of melanocytes
during embryogenesis because mutations in either the SCF gene, or its ligand, c‐kit, result …

The cKit receptor plays a critical role in melanocyte physiology, influencing melanogenesis,
proliferation, migration, and survival of the pigment-producing cells. However, pathways of …

Stem cell factor (SCF) is synthesized as both soluble (S) and membrane-associated (MA)
proteins. Indirect insight into the function of MA and S isoforms of SCF has come from …