Background Folic acid taken in early pregnancy reduces risks for delivering offspring with
several congenital anomalies. The mechanism by which folic acid reduces risk is unknown …

Women who consume folic acid in early pregnancy reduced their risks for delivering
offspring with neural tube defects (NTDs). The underlying process by which folic acid …

Neural tube defects (NTDs) are common, serious malformations with a complex etiology that
suggests involvement of both genetic and environmental factors. The authors evaluated …

Although a reduction in incidence of neural tube defects is unequivocally linked to adequate
folate status, evidence is also mounting associating folate with other fetal malformations. The …

Background—Although congenital heart defects (CHD) are the most common and serious
group of birth defects, relatively little is known about the causes of these conditions and …

Objective: To investigate the contribution of polymorphic variation in genes involved in the
folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD) …

Clues regarding candidate genes which influence susceptibility to spina bifida and
anencephaly come from the identification of folate-associated risk factors and from studies of …

BACKGROUND: Spina bifida is a class of neural tube defects, which are congenital
malformations of the central nervous system with a prevalence of 0.5 to 12 per 1000 births …

Background: The US Food and Drug Administration mandated that enriched grain products
be fortified with folic acid by 1998. We evaluated whether intake of folic acid from …

Women planning a pregnancy and pregnant women in the first trimester are recommended
to use folate-containing supplements in order to prevent neural tube defects. The prevention …