Breast cancers commonly cause osteolytic metastases in bone, a process that is dependent
upon osteoclast-mediated bone resorption, but the mechanism responsible for tumor …

Bone metastasis is an incurable complication of breast cancer. In advanced stages, patients
with estrogen-positive tumors experience a significantly higher incidence of bone metastasis …

Aims The estrogen-ERα axis participates in osteoblast maturation. This study was designed
to further evaluated the roles of the estrogen-ERα axis in bone healing and the possible …

Abstract 17β-Estradiol can promote the growth and development of several estrogen
receptor (ER)-negative breast cancers. The effects are rapid and non-genomic, suggesting …

The role of estrogen signaling in regulating prostate tumorigenesis is relatively
underexplored. Although, an increasing body of evidence has linked estrogen receptor beta …

Osteosarcoma (OS) is a malignant tumor mainly occurring in children and adolescents.
Methotrexate (MTX), a chemotherapy agent, is widely used in treating OS. However …

Background Bone is one of the most frequent metastatic sites of advanced breast cancer.
Current therapeutic agents aim to inhibit osteoclast-mediated bone resorption but only have …

Objective Estrogen receptor alpha 36 (ER-α36), a truncated variant of ER-α, is different from
other nuclear receptors of the ER-α family. Previous findings indicate that ER-α36 might be …

Estrogen receptor-alpha 36 (ER-α36) is a variant of ER-α that has been found to be
expressed in conventional ER (ER-α66)-negative breast cancer cell lines and human breast …

Most breast cancer patients develop bone metastasis and bone-related complications at the
late stage of the disease irrespective of the subtypes. Breast cancer destroys bones by …