Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review

SA Sousa, JR Feliciano, T Pita, SI Guerreiro, JH Leitão - Genes, 2017 - mdpi.com
Burkholderia cepacia complex (Bcc) bacteria emerged as opportunistic pathogens in cystic
fibrosis and immunocompromised patients. Their eradication is very difficult due to the high …

Burkholderia cenocepacia Differential Gene Expression during Host–Pathogen Interactions and Adaptation to the Host Environment

EP O'Grady, PA Sokol - Frontiers in Cellular and Infection …, 2011 - frontiersin.org
Members of the Burkholderia cepacia complex (Bcc) are important in medical,
biotechnological, and agricultural disciplines. These bacteria naturally occur in soil and …

Genomic Expression Analysis Reveals Strategies of Burkholderia cenocepacia to Adapt to Cystic Fibrosis Patients' Airways and Antimicrobial Therapy

NP Mira, A Madeira, AS Moreira, CP Coutinho… - PLoS …, 2011 - journals.plos.org
Pulmonary colonization of cystic fibrosis (CF) patients with Burkholderia cenocepacia or
other bacteria of the Burkholderia cepacia complex (Bcc) is associated with worse prognosis …

Potential of metabolomics to reveal Burkholderia cepacia complex pathogenesis and antibiotic resistance

NS Shommu, HJ Vogel, DG Storey - Frontiers in Microbiology, 2015 - frontiersin.org
The Burkholderia cepacia complex (Bcc) is a collection of closely related, genetically
distinct, ecologically diverse species known to cause life-threatening infections in cystic …

Evolution towards Virulence in a Burkholderia Two-Component System

MM Schaefers, BX Wang, NM Boisvert, SJ Martini… - MBio, 2021 - Am Soc Microbiol
Bacteria in the Burkholderia cepacia complex (BCC) are significant pathogens for people
with cystic fibrosis (CF) and are often extensively antibiotic resistant. Here, we assess the …

Long-Term Colonization of the Cystic Fibrosis Lung by Burkholderia cepacia Complex Bacteria: Epidemiology, Clonal Variation, and Genome-Wide Expression …

CP Coutinho, SC Dos Santos, A Madeira… - Frontiers in cellular …, 2011 - frontiersin.org
Long-term respiratory infections with Burkholderia cepacia complex (Bcc) bacteria in cystic
fibrosis (CF) patients generally lead to a more rapid decline in lung function and, in some …

The multifarious, multireplicon Burkholderia cepacia complex

E Mahenthiralingam, TA Urban… - Nature Reviews …, 2005 - nature.com
Abstract The Burkholderia cepacia complex (Bcc) is a collection of genetically distinct but
phenotypically similar bacteria that are divided into at least nine species. Bcc bacteria are …

The Role of Mucoidy in Virulence of Bacteria from the Burkholderia cepacia Complex: A Systematic Proteomic and Transcriptomic Analysis

JEA Zlosnik, DP Speert - The Journal of infectious diseases, 2010 - academic.oup.com
Bacteria of the Burkholderia cepacia complex (BCC) are associated with severe infection in
cystic fibrosis. Recent evidence shows that the mucoid phenotype is common in BCC …

Proteomic identification and characterization of bacterial factors associated with Burkholderia cenocepacia survival in a murine host

JW Chung, DP Speert - Microbiology, 2007 - microbiologyresearch.org
Burkholderia cenocepacia is a member of the Burkholderia cepacia complex, a diverse
family of Gram-negative bacteria that are serious respiratory pathogens in …

Comparative Evolutionary Patterns of Burkholderia cenocepacia and B. multivorans During Chronic Co-infection of a Cystic Fibrosis Patient Lung

AA Hassan, SC Dos Santos, VS Cooper… - Frontiers in …, 2020 - frontiersin.org
During chronic respiratory infections of cystic fibrosis (CF) patients, bacteria adaptively
evolve in response to the nutritional and immune environment as well as influence other …