Autophagy is an intracellular degradation pathway that functions in protein and organelle
turnover in response to starvation and cellular stress. Autophagy is initiated by the formation …

Autophagy is the principal cellular pathway for degradation of long-lived proteins and
organelles and regulates cell fate in response to stress. Recently, autophagy has been …

Impairment of the autophagy pathway has been observed during the pathogenesis of
Alzheimer's disease (AD), a neurodegenerative disorder characterized by abnormal …

The accumulation of amyloid-β-containing neuritic plaques and intracellular tau protein
tangles are key histopathological hallmarks of Alzheimer's disease (AD). This type of …

The regulation of plasma membrane (PM)-localized transmembrane protein/receptor
trafficking has critical implications for cell signaling, metabolism and survival. In this study …

Beclin 1 is a protein involved in the regulation of autophagy and has been shown to be
reduced in patients with Alzheimer disease. This review summarizes the current research …

The degradation of macromolecules and organelles by the process of autophagy is critical
for cellular homeostasis and is often compromised during aging and disease. Beclin1 and …

Autophagy is a tightly regulated catabolic process wherein cells under stress sequester
cytosolic constituents like damaged proteins and organelles in double-membrane vesicles …

Autophagy is a conserved intracellular degradation pathway essential for protein
homeostasis, survival and development. Defects in autophagic pathways have been …

The molecular mechanism of autophagy and its relationship to other lysosomal degradation
pathways remain incompletely understood. Here, we identified a previously uncharacterized …