Men with high-grade prostatic intraepithelial neoplasia (PIN) evident on prostate biopsy are
at high risk for the eventual development of prostate cancer. The ability to reverse high …

This review summarizes published data dealing with the prevalence of high-grade prostatic
intraepithelial neoplasia (HGPIN) in a variety of prostate tissue samples. Additionally, we …

Flutamide is a nonsteroidal antiandrogen that is frequently used for total androgen blockage
in the treatment of advanced prostate cancer. We investigated the effect of this antiandrogen …

Aim: To explore the effect of androgen receptor (AR) on the expression of the cell cycle‐
related genes, such as CDKN1A and BTG1, in prostate cancer cell line LNCaP. Methods …

High-grade prostatic intraepithelial neoplasia (HGPIN) is a premalignant lesion associated
with increased risk of coexistent cancer or delayed progression to carcinoma. Extended …

RESULTS: An immotile cell line, SO-RY, was successfully established, and it has been
maintained over 100 passages. The doubling time of SO-RY was 96 hours. Chromosomal …

PURPOSE: We determined the chemopreventive effect of the antiandrogen bicalutamide
(Zeneca Co., Ltd., Osaka, Japan) on Fisher 344 rat prostate carcinogenesis induced by …

Backgroound The best treatment for patients with “hormone-refractory” metastatic prostate
cancer is unclear, particularly in patients for whom suramin and hydrocortisone have failed …

We read with great interest the recent CUA guidelines on prostate biopsy methodology. 1
We note that the recommendation regarding high-grade prostatic intra-epithelial neoplasia …

High‐grade prostatic intraepithelial neoplasia (HGPIN) is a documented putative precursor
lesion for invasive prostate adenocarcinoma. However, the precise mechanisms of the …