NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

The NOD-, LRR-and pyrin domain-containing protein 3 (NLRP3) inflammasome is a
cytoplasmic supramolecular complex that is activated in response to cellular perturbations …

Introduction NOD-like receptor family pyrin domain containing 3 (NLRP3) can sense a
plethora of exogenous and endogenous dangers. Upon activation, a multimeric protein …

Inflammasomes are large macromolecular signaling complexes that control the proteolytic
activation of two highly proinflammatory IL-1 family cytokines, IL-1β and IL-18. The NLRP3 …

Highlights•Targeting the NLRP3 inflammasome has shown therapeutic effects in
inflammatory diseases.•The use of specific NLRP3 inhibitors reduces off-target …

The NLRP3 inflammasome is activated in response to a variety of signals that are indicative
of damage to the host including tissue damage, metabolic stress, and infection. Upon …

The NLRP3 inflammasome is a cytoplasmic multiprotein complex, the assembly of which
can be initiated in response to various exogenous or endogenous danger signals …

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-
associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) …

Inflammasomes are cytosolic multiprotein complexes that cause the release of biologically
active interleukin‐1β. The best‐characterized inflammasome is the NLRP3 (nucleotide …

Nucleotide-binding oligomerization domain NOD-like receptors (NLRs) are conserved
cytosolic pattern recognition receptors (PRRs) that track the intracellular milieu for the …