Inflammasomes are protein complexes which are important in several inflammatory
diseases. Inflammasomes form part of the innate immune system that triggers the activation …

NACHT, LRR (leucine-rich repeat), and PYD (pyrin domain) domain-containing 6 (Nlrp6) is
a member of the NLR (nucleotide-oligomerization domain-like receptor) family that patrols …

Summary 15 years ago, the fundamental biology of an inflammatory signaling complex
eventually dubbed “the inflammasome” began to unravel in chronologic parallel with the …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Abstract NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) is an intracellular
sensor that detects a broad range of microbial motifs, endogenous danger signals and …

Members of the nucleotide-binding domain and leucine-rich repeat (LRR)-containing (NLR)
family and the pyrin and HIN domain (PYHIN) family can form multiprotein complexes …

The inflammasome regulates innate immunity by serving as a signaling platform. The Nod‑
like receptor protein 3 (NLRP3) inflammasome, equipped with NLRP3, the adaptor protein …

NLRP3 inflammasome is an intracellular protein complex that initiates cellular injury via
assembly of NLRP3, ASC and caspase-1 in response to microbial infection and sterile …

Inflammasomes are multi-protein signaling complexes that trigger the activation of
inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome …