Inflammasomes are supramolecular complexes that form in the cytosol in response to
pathogen-associated and damage-associated stimuli, as well as other danger signals that …

Chronic unresolving inflammation is emerging as a key underlying pathological feature of
many if not most diseases ranging from autoimmune conditions to cardiometabolic and …

Objectives Inflammasomes are multiprotein complexes that sense pathogens and trigger
biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like …

The protein NLRP3 has emerged as a central regulator in the inflammatory process, being
implicated directly in hereditary cryopyrinopathies, and indirectly in diseases such as gout …

NLRP3 is the best characterized cytosolic nod-like pattern recognition receptor which can
detect microbial motifs, endogenous danger and stress signals. Activation of NLRP3 leads to …

Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Inflammasomes are multiprotein complexes that drive inflammation and contribute to
protective immunity against pathogens and immune pathology in autoinflammatory …

Inflammasomes are a group of protein complex located in cytoplasm and assemble in
response to a wide variety of pathogen‐associated molecule patterns, damage‐associated …