In the last decades, the extension of life expectancy and the increased consumption of foods
rich in saturated fats and added sugars have exposed the general population to emerging …

Nuclear receptors are important bridges between lipid signaling molecules and transcription
responses. Beside their role in several developmental and physiological processes, many of …

Highlights•The NLRP3, NLRC4, and pyrin inflammasomes are regulated by post-
translational modifications.•The Dhx9-NLRP9b inflammasome recognizing viral dsRNA was …

Objectives Inflammasomes induce maturation of the inflammatory cytokines IL‐1β and IL‐18,
whose activity is associated with the pathophysiology of a wide range of infectious and …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

NLRP3 inflammasomes have recently emerged as an attractive drug target for
neurodegenerative disorders. In our continuing studies, a new chemical scaffold was …

Abstract NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune
sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon …

The NACHT, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3
(NLRP3) inflammasome is an intracellular sensing protein complex that plays a major role in …

Inflammasomes are specialized inflammatory signaling platforms that govern the maturation
and secretion of proinflammatory cytokines, such as IL-1β and IL-18, through the regulation …

ABSTRACT The NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
inflammasome is a fascinating cellular machinery endowed with the capacity for rapid …