APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …

People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of
developing renal diseases. However, the mechanisms underlying APOL1-associated renal …

Background Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are
associated with large increases in CKD rates among populations of recent African descent …

Population genetic approaches have uncovered a strong association between kidney
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and …

Coding variants in the APOL1 gene are associated with kidney diseases in African ancestral
populations; yet, the underlying biologic mechanisms remain uncertain. Variant-dependent …

African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

The apolipoprotein L1 (APOL1) gene is unique to humans and gorillas and appeared~ 33
million years ago. Since the majority of the mammals do not carry APOL1, it seems to be …

Background: Genetic variants in APOL1 are a major contributor to the increased risk of
kidney disease in people of recent African ancestry. Summary: Two alleles in the APOL1 …

Two specific genetic variants of the apolipoprotein L1 (APOL1) gene are responsible for the
high rate of kidney disease in people of recent African ancestry. Expression in cultured cells …

APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of
renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to …