Tau aggregation in neurofibrillary tangles (NFTs) is closely associated with
neurodegeneration and cognitive decline in Alzheimer's disease (AD). However, the …

Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular
amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles …

Tau protein accumulation is the most common pathology among degenerative brain
diseases, including Alzheimer's disease (AD), progressive supranuclear palsy (PSP) …

Neurofibrillary tangles (NFTs) are associated with neuronal loss and correlate with cognitive
impairment in Alzheimer disease, but how NFTs relate to neuronal death is not clear. We …

Here, we describe the generation of a novel transgenic mouse model of human tauopathy.
The rTg (tauP301L) 4510 mouse expresses the P301L mutation in tau (4R0N) associated …

Neurofibrillary tangles, one of the neuropathologic hallmarks of Alzheimer's disease, have a
dynamic lifespan of maturity that associates with progressive neuronal dysfunction and …

Neurofibrillary tangles (NFTs) are composed of abnormal aggregates of the cytoskeletal
protein tau. Together with amyloid β (Aβ) plaques and neuronal and synaptic loss, NFTs …

Neurofibrillary tangles (NFTs) are a pathological hallmark of Alzheimer's disease (AD);
however, the relationship between NFTs and disease progression remains controversial …

Alzheimer's disease is a chronic, age‐related neurodegenerative disorder. Neurofibrillary
tangles are among the pathological hallmarks of Alzheimer's disease. Neurofibrillary tangles …

Development of neurofibrillary tangles (NFTs) is a pathological hallmark in various
neurodegenerative disorders including Alzheimer's disease (AD). Recently, we identified a …