The total synthesis of long proteins requires the assembly of multiple fragments through
successive ligations. The need for intermediate purification steps is a strong limitation …

The native chemical ligation reaction has been used extensively for the synthesis of the
large polypeptides that correspond to folded proteins and domains. The efficiency of the …

Chemical synthesis is a complementary alternative to recombinant approaches for the
production of small (40–80 amino acids) to medium-sized (60–200 amino acids) proteins …

Chemical ligation of unprotected peptides has enabled the successful synthesis of a large
number of diverse proteins.[1] The native chemical ligation (NCL) reaction,[2] which …

Protein chemical synthesis by native peptide ligation of unprotected peptide segments is an
interesting complement and potential alternative to the use of living systems for producing …

In recent years, there has been an explosion of interest in protein-assembly technologies
such as native chemical ligation (NCL)[1] and expressed protein ligation (EPL).[2] NCL …

In this paper we describe “solid phase chemical ligation”(SPCL), the application of the
principles of polymer-supported organic synthesis to the construction of large polypeptide …

Chemical synthesis is the most powerful way to assemble selectively modified proteins and
is a tool for engineering proteins that are inaccessible by standard site-directed …

Chemical protein synthesis gives access to well-defined native or modified proteins that are
useful for studying protein structure and function. The majority of proteins synthesized up to …

Convergent chemical ligation enables the more efficient total synthesis of protein molecules.
SBH Kent and co‐workers describe in their Communication on page 3985 ff. how the two …