Is there a place for genetics in the management of PONV?

K Candiotti, C Shrestha, MRS Ceschim - Best Practice & Research Clinical …, 2020 - Elsevier
Antiemetic prophylaxis for postoperative nausea and vomiting (PONV)–a frequent
complication in the postoperative period–is routinely given to high-risk patients. However …

[HTML][HTML] Genetic susceptibility toward nausea and vomiting in surgical patients

Y Gloor, C Czarnetzki, F Curtin, B Gil-Wey… - Frontiers in …, 2022 - frontiersin.org
Postoperative nausea and vomiting (PONV) are frequently occurring adverse effects
following surgical procedures. Despite predictive risk scores and a pallet of prophylactic …

Genetic variability in postoperative nausea and vomiting: A systematic review

S Klenke, UH Frey - European Journal of Anaesthesiology| EJA, 2020 - journals.lww.com
BACKGROUND Postoperative nausea and vomiting (PONV) is the most frequent side effect
following anaesthesia. Predisposition to developing PONV is multifactorial with patient risk …

Clinical and genetic factors associated with post‐operative nausea and vomiting after propofol anaesthesia

SE Ahlström, PH Bergman, RM Jokela… - Acta …, 2023 - Wiley Online Library
Background The incidence of post‐operative nausea and vomiting (PONV) remains at about
30% despite all therapeutic efforts to reduce it. The clinical risk factors guiding the …

[HTML][HTML] Postoperative nausea and vomiting

YE Moon - Korean journal of anesthesiology, 2014 - synapse.koreamed.org
Postoperative nausea and vomiting (PONV) is a long-standing issue, not a new concept in
anesthesiology. Despite many studies over the last several decades, PONV remains a …

Pharmacogenetics of postoperative nausea and vomiting

EN Aroke, TL Hicks - Journal of PeriAnesthesia Nursing, 2019 - Elsevier
Postoperative nausea and vomiting (PONV) remains one of the most common adverse
effects of anesthesia, affecting up to 80% of high-risk patients within 24 hours after surgery …

[HTML][HTML] Risk-tailored prophylaxis for postoperative nausea and vomiting: still a messy issue

R Landau, PK Janicki - British Journal of Anaesthesia, 2018 - bjanaesthesia.org
Much has been written about risk stratification and effectiveness of postoperative nausea
and vomiting (PONV) prophylaxis, and the challenges so far have consisted in identifying (i) …

Genetic contribution to PONV risk

S Klenke, GJ de Vries, L Schiefer, N Seyffert… - … Critical Care & Pain …, 2020 - Elsevier
Background Clinical risk factors for postoperative nausea and vomiting (PONV) are usually
stratified using the Apfel Score. While a genetic predisposition has recently been …

Genome-wide association study using pooled DNA to identify candidate markers mediating susceptibility to postoperative nausea and vomiting

PK Janicki, R Vealey, J Liu, J Escajeda… - The Journal of the …, 2011 - pubs.asahq.org
Background A family history has been established as a risk factor for postoperative nausea
and vomiting (PONV), but the identities of susceptibility genes remain unknown. The goal of …

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

CC Horn, WJ Wallisch, GE Homanics… - European journal of …, 2014 - Elsevier
Clinical research shows that postoperative nausea and vomiting (PONV) is caused primarily
by the use of inhalational anesthesia and opioid analgesics. PONV is also increased by …