Myocardial reperfusion therapy is the optimal therapeutic strategy for acute myocardial
infarction. However, the subsequent ischemia and reperfusion (I/R) injury may attenuate the …

Background—Reactive oxygen species (ROS) play an important role in the maintenance of
cardiovascular homeostasis. The present study sought to determine whether nuclear factor …

Myocardial reperfusion therapy is the most important therapeutic strategy for myocardial
infarction (MI) by reversing myocardial ischemia and reducing the infarct size. However, the …

The morbidity rate of myocardial ischemia and reperfusion has increased in modern society,
and oxidative stress plays a critical role in the pathological process. Nuclear factor E2 …

Heart failure (HF) is frequently the consequence of sustained, abnormal neurohormonal,
and mechanical stress and remains a leading cause of death worldwide. The key …

Nuclear factor erythroid-2 related factor 2 (Nrf2), a nuclear transcription factor, modulates
genes responsible for antioxidant responses against toxic and oxidative stress to maintain …

Aims Nuclear factor erythroid-2-related factor 2 (Nrf2) appears to be a negative regulator of
maladaptive cardiac remodelling and dysfunction; however, a potential of the Nrf2-mediated …

Background NF-E2-related factor 2 (Nrf2) is a transcription factor playing cytoprotective
effects in various pathological processes including oxidative stress and cardiac hypertrophy …

Increased production of reactive oxygen species and failure of the antioxidant defense
system are considered to play a central role in the pathogenesis of cardiovascular disease …

Nuclear factor erythroid-2–related factor 2 (Nrf2) appears to exert either a protective or
detrimental effect on the heart; however, the underlying mechanism remains poorly …