Obesity-associated insulin resistance is a complex disorder involving a number of candidate
molecules, pathways and transduction systems possessing potential causal actions …

Adipose tissue depots can exist in close association with other organs, where they assume
diverse, often non-traditional functions. In stem cell-rich skin, bone marrow, and mammary …

When caloric intake exceeds caloric expenditure, the positive caloric balance and storage of
energy in adipose tissue often causes adipocyte hypertrophy and visceral adipose tissue …

Recent findings, notably on adipokines and adipose tissue inflammation, have revised the
concept of adipose tissues being a mere storage depot for body energy. Instead, adipose …

Adipose tissue (AT) plays a central role in both metabolic health and pathophysiology. Its
expansion in obesity results in increased mortality and morbidity, with contributions to …

Rather than serving as a mere onlooker, adipose tissue is a complex endocrine organ and
active participant in disease initiation and progression. Disruptions of biological processes …

Obesity is a risk factor for various cardiovascular diseases including hypertension,
atherosclerosis, and myocardial infarction. Recent studies aimed at understanding the …

Obesity plays a causative role in the pathogenesis of the metabolic syndrome. Adipokines
may link obesity to its co-morbidities. Most adipokines with pro-inflammatory properties are …

Obesity is characterized by a state of chronic inflammation in adipose tissue mediated by the
secretion of a range of inflammatory cytokines. In comparison to WAT, relatively little is …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …