Gas chromatography-mass spectrometry (GC-MS)-based metabolomics

A Garcia, C Barbas - Metabolic profiling: Methods and protocols, 2011 - Springer
Metabolic fingerprinting, the main tool in metabolomics, is a non-targeted methodology
where all detectable peaks (or signals), including those from unknown analytes, are …

High-throughput data analysis for detecting and identifying differences between samples in GC/MS-based metabolomic analyses

P Jonsson, AI Johansson, J Gullberg, J Trygg… - Analytical …, 2005 - ACS Publications
In metabolomics, the objective is to identify differences in metabolite profiles between
samples. A widely used tool in metabolomics investigations is gas chromatography− mass …

Metabolomics by gas chromatography–mass spectrometry: Combined targeted and untargeted profiling

O Fiehn - Current protocols in molecular biology, 2016 - Wiley Online Library
Gas chromatography–mass spectrometry (GC‐MS)–based metabolomics is ideal for
identifying and quantitating small‐molecule metabolites (< 650 Da), including small acids …

metaMS: An open-source pipeline for GC–MS-based untargeted metabolomics

R Wehrens, G Weingart, F Mattivi - Journal of Chromatography B, 2014 - Elsevier
Untargeted metabolomics are rapidly becoming an important tool for studying complex
biological samples. Gas chromatography–mass spectrometry (GC–MS) is the most widely …

TagFinder: preprocessing software for the fingerprinting and the profiling of gas chromatography–mass spectrometry based metabolome analyses

A Luedemann, L von Malotky, A Erban… - … : Methods and protocols, 2012 - Springer
GC-MS based metabolome studies aim for the complete identification and relative or
absolute quantification of metabolites in complex extracts from a large diversity of biological …

Untargeted GC-MS Metabolomics

MEP Papadimitropoulos, CG Vasilopoulou… - … profiling: Methods and …, 2018 - Springer
Untargeted metabolomics refers to the high-throughput analysis of the metabolic state of a
biological system (eg, tissue, biological fluid, cell culture) based on the concentration profile …

Extending the breadth of metabolite profiling by gas chromatography coupled to mass spectrometry

O Fiehn - TrAC Trends in Analytical Chemistry, 2008 - Elsevier
Gas chromatography coupled to mass spectrometry (GC-MS) is one of the most frequently
used tools for profiling primary metabolites. Instruments are mature enough to run large …

A strategy for identifying differences in large series of metabolomic samples analyzed by GC/MS

P Jonsson, J Gullberg, A Nordström… - Analytical …, 2004 - ACS Publications
In metabolomics, the purpose is to identify and quantify all the metabolites in a biological
system. Combined gas chromatography and mass spectrometry (GC/MS) is one of the most …

Review of recent developments in GC–MS approaches to metabolomics-based research

DJ Beale, FR Pinu, KA Kouremenos, MM Poojary… - Metabolomics, 2018 - Springer
Background Metabolomics aims to identify the changes in endogenous metabolites of
biological systems in response to intrinsic and extrinsic factors. This is accomplished …

Practical non-targeted gas chromatography/mass spectrometry-based metabolomics platform for metabolic phenotype analysis

H Tsugawa, T Bamba, M Shinohara, S Nishiumi… - Journal of bioscience …, 2011 - Elsevier
Gas chromatography coupled to mass spectrometry (GC/MS) is a core analytical method for
metabolomics and has been used as a platform in non-targeted analysis, especially for …