Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

[图书][B] Metabolomics: methods and protocols

W Weckwerth - 2008 - books.google.com
Metabolomics: Methods and Protocols examines the state-of-the-art in metabolomic
analysis. Leading researchers in the field present protocols for the application of …

MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis

K Hiller, J Hangebrauk, C Jäger, J Spura… - Analytical …, 2009 - ACS Publications
We have developed a new software, MetaboliteDetector, for the efficient and automatic
analysis of GC/MS-based metabolomics data. Starting with raw MS data, the program …

Development and performance of a gas chromatography− time-of-flight mass spectrometry analysis for large-scale nontargeted metabolomic studies of human serum

P Begley, S Francis-McIntyre, WB Dunn… - Analytical …, 2009 - ACS Publications
A method for the preparation and GC− TOF-MS analysis of human serum samples has been
developed and evaluated for application in long-term metabolomic studies. Serum samples …

Quantitative metabolomics based on gas chromatography mass spectrometry: status and perspectives

MM Koek, RH Jellema, J van der Greef, AC Tas… - Metabolomics, 2011 - Springer
Metabolomics involves the unbiased quantitative and qualitative analysis of the complete set
of metabolites present in cells, body fluids and tissues (the metabolome). By analyzing …

TargetSearch-a Bioconductor package for the efficient preprocessing of GC-MS metabolite profiling data

A Cuadros-Inostroza, C Caldana, H Redestig… - BMC …, 2009 - Springer
Background Metabolite profiling, the simultaneous quantification of multiple metabolites in
an experiment, is becoming increasingly popular, particularly with the rise of systems-level …

Improving the quality of biomarker candidates in untargeted metabolomics via peak table-based alignment of comprehensive two-dimensional gas chromatography …

HD Bean, JE Hill, JMD Dimandja - Journal of Chromatography A, 2015 - Elsevier
The potential of high-resolution analytical technologies like GC× GC/TOF MS in untargeted
metabolomics and biomarker discovery has been limited by the development of fully …

Data processing for mass spectrometry-based metabolomics

M Katajamaa, M Orešič - Journal of chromatography A, 2007 - Elsevier
Modern analytical technologies afford comprehensive and quantitative investigation of a
multitude of different metabolites. Typical metabolomic experiments can therefore produce …

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

WB Dunn, A Erban, RJM Weber, DJ Creek, M Brown… - Metabolomics, 2013 - Springer
Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

[HTML][HTML] Optimizing 2D gas chromatography mass spectrometry for robust tissue, serum and urine metabolite profiling

Z Yu, H Huang, A Reim, PD Charles, A Northage… - Talanta, 2017 - Elsevier
Two-dimensional gas chromatography mass spectrometry (GCxGC-MS) is utilized to an
increasing extent in biomedical metabolomics. Here, we established and adapted …