Angiogenesis is the growth of new capillaries from the preexisting blood vessels.
Glioblastoma (GBM) tumors are highly vascularized tumors, and glioma growth depends on …

Gliomas are the most frequent primary tumors of the central nervous system in adults.
Glioblastoma multiforme, the most aggressive form of astrocytic tumors, displays a rapid …

Angiogenesis is a key event in the progression of malignant gliomas. The presence of
microvascular proliferation leads to the histological diagnosis of glioblastoma multiforme …

Antiangiogenesis approaches have the potential to be particularly effective in the treatment
of glioblastoma tumours. These tumours exhibit extremely high levels of neovascularisation …

The poor prognosis of patients with malignant brain tumors in spite of aggressive
multimodality therapy has led to the search for novel therapeutic strategies. Among the …

Currently, adult glioblastoma (GBM) patients have poor outcomes with conventional
cytotoxic treatments. Because GBMs are highly angiogenic tumors, inhibitors that target …

Progressive tumor growth depends on angiogenesis to sustain metabolic needs of tumor
cells, thus providing a potential target for cancer therapy. Malignant gliomas have retained …

Due to the prominent angiogenesis that occurs in malignant glioma, antiangiogenic therapy
has been attempted. There have been several molecular targets that are specific to …

The prognosis of malignant gliomas is still dismal despite aggressive treatment attempts.
Thus, alternative therapy strategies are needed. Malignant gliomas are upon the best …

The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-
angiogenic cancer therapy are major issues in almost all current concepts of both cancer …