Overcoming obstacles in microRNA delivery towards improved cancer therapy

D Ben-Shushan, E Markovsky, H Gibori… - Drug delivery and …, 2014 - Springer
MicroRNAs (miRNAs) are small noncoding RNAs found to govern nearly every biological
process. They frequently acquire a gain or a loss of function in cancer, hence playing a …

Nanocarriers for microRNA delivery in cancer medicine

I Fernandez-Piñeiro, I Badiola, A Sanchez - Biotechnology advances, 2017 - Elsevier
The number of deaths caused by cancer is expected to increase partly due to the lack of
selectivity and undesirable systemic effects of current treatments. Advances in the …

A comprehensive review of cancer MicroRNA therapeutic delivery strategies

A Forterre, H Komuro, S Aminova, M Harada - Cancers, 2020 - mdpi.com
In the field of molecular oncology, microRNAs (miRNAs) and their role in regulating
physiological processes and cancer pathogenesis have been a revolutionary discovery over …

MicroRNAs and their big therapeutic impacts: delivery strategies for cancer intervention

C Holjencin, A Jakymiw - Cells, 2022 - mdpi.com
Three decades have passed from the initial discovery of a microRNA (miRNA) in
Caenorhabditis elegans to our current understanding that miRNAs play essential roles in …

Non-viral nanocarriers for intracellular delivery of microRNA therapeutics

Z Bai, J Wei, C Yu, X Han, X Qin, C Zhang… - Journal of Materials …, 2019 - pubs.rsc.org
MicroRNAs are small regulatory noncoding RNAs that regulate various biological processes
associated with neurological disorders, cardiovascular diseases, cancer and viral infection …

Therapeutic microRNA delivery strategies with special emphasis on cancer therapy and tumorigenesis: current trends and future challenges

C Chakraborty, ZH Wen… - Current drug …, 2016 - ingentaconnect.com
Background: Over the decade, miRNAs are the most important molecules for the
biopharmaceutical industry due to their relation with several human diseases. Presently, the …

Lipid nanoparticles to deliver miRNA in cancer

V Campani, G De Rosa, G Misso… - Current …, 2016 - ingentaconnect.com
MicroRNAs (miRNAs) are a class of post-transcriptional gene expression modulators. In the
past two decades, over 1500 human miRNAs were discovered. These small non-coding …

miRNA delivery by nanosystems: state of the art and perspectives

FC Moraes, C Pichon, D Letourneur, F Chaubet - Pharmaceutics, 2021 - mdpi.com
MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …

Non-viral based miR delivery and recent developments

AE Labatut, G Mattheolabakis - European Journal of Pharmaceutics and …, 2018 - Elsevier
Abstract miRNAs are promising therapeutic targets or tools for the treatment of numerous
diseases, with most prominently, cancer. The inherent capacity of these short nucleic acids …

Delivery of therapeutic miRNA using polymer-based formulation

E Ban, TH Kwon, A Kim - Drug delivery and translational research, 2019 - Springer
MicroRNAs (miRNAs) are short non-coding RNAs that play important roles in many cellular
processes such as development, proliferation, differentiation, and apoptosis. For this reason …