Mitochondria are responsible for the majority of energy production in energy-intensive
tissues like brain, modulate Ca+ 2 signaling and control initiation of cell death. Because of …

A growing body of evidence suggests that mitochondrial abnormalities are involved in aging
and in age-related neurodegenerative diseases as well as cancer, diabetes, and several …

Mitochondria have been long known as “gatekeepers of life and death”. Indeed, these
dynamic organelles are the master coordinators of energy metabolism, being responsible for …

Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases
leading to the generation of lipid peroxides, carbonyl proteins and oxidative DNA damage in …

In 1907 Alois Alzheimer observed, as he quoted, development of “numerous fibers” and
“adipose saccules” in the brain of his diseased patient Auguste Deter. The …

Although the pathogenesis of neurodegenerative diseases is still widely unclear, various
mechanisms have been proposed and several pieces of evidence are supportive for an …

In neurons, mitochondria are enriched to provide energy and calcium buffering required for
synaptic transmission. Additionally, mitochondria localize to the synapse, where they are …

Alzheimer's disease (AD) is a leading neurodegenerative pathology associated with aging
worldwide. It is estimated that AD prevalence will increase from 5.8 million people today to …

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases,
characterized by impaired cognitive function due to progressive loss of neurons in the brain …