The role of natural product chemistry in drug discovery

MS Butler - Journal of natural products, 2004 - ACS Publications
Although traditionally natural products have played an important role in drug discovery, in
the past few years most Big Pharma companies have either terminated or considerably …

Natural products as drugs and leads to drugs: the historical perspective

DJ Newman, GM Cragg - 2009 - books.rsc.org
It is always a little difficult to know where to start and when to stop in time when discussing
the historical influence of natural products upon drug discovery because, even today …

[HTML][HTML] Rediscovering natural products as a source of new drugs

FE Koehn, GT Carter - Discovery medicine, 2009 - discoverymedicine.com
Advanced technologies such as high-throughput screening and combinatorial chemistry
have taken the center stage in drug discovery, but they have yet to reach the the level …

Natural products as a foundation for drug discovery

JA Beutler - Current protocols in pharmacology, 2019 - Wiley Online Library
Many natural products have been used as drugs for the treatment of diverse indications.
Although most US pharmaceutical companies have reduced or eliminated their in‐house …

Plant-derived chemicals: A source of inspiration for new Drugs

V Seidel - Plants, 2020 - mdpi.com
Plants have a long history of use as traditional remedies to treat a range of diseases and the
diverse chemicals that they produce have provided great inspiration for the design of new …

[引用][C] Natural products: chemistry, biochemistry and pharmacology

G Brahmachari - 2009 - Alpha Science International, Limited

The evolving role of natural products in drug discovery

FE Koehn, GT Carter - Nature reviews Drug discovery, 2005 - nature.com
Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …

Natural products: a continuing source of inspiration for the medicinal chemist

SMN Efange - Advances in phytomedicine, 2002 - Elsevier
The study of naturally occurring compounds has led to innumerable advances in
pharmacology and medicine. For the medicinal chemist, a biologically active natural …

Natural products as a foundation for drug discovery

JA Beutler - Current protocols in pharmacology, 2009 - Wiley Online Library
Natural products have provided chemical leads for the development of many drugs for
diverse indications. While most US pharmaceutical firms have reduced or eliminated their in …

Natural products and Pharma 2011: Strategic changes spur new opportunities

GT Carter - Natural product reports, 2011 - pubs.rsc.org
Although natural products have been marginalized by major pharmaceutical companies
over the last 20–30 years, the changing landscape of drug discovery now favors a greatly …