[HTML][HTML] Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight …
HF Ji, XJ Li, HY Zhang - EMBO reports, 2009 - embopress.org
The medicinal use of natural prod-ucts—compounds that are derived from natural sources
such as plants, animals or micro-organisms—precedes recorded human history probably by …
such as plants, animals or micro-organisms—precedes recorded human history probably by …
[HTML][HTML] The success of natural products in drug discovery
M Lahlou - 2013 - scirp.org
Drug discovery leading to robust and viable lead candidates' remains a challenging
scientific task, which is the transition from a screening hit to a drug candidate, requires …
scientific task, which is the transition from a screening hit to a drug candidate, requires …
[图书][B] Plant-derived natural products
AE Osbourn, V Lanzotti - 2009 - Springer
Plants produce a huge array of natural products (secondary metabolites). These compounds
have important ecological functions, providing protection against attack by herbivores and …
have important ecological functions, providing protection against attack by herbivores and …
[HTML][HTML] Natural products for drug discovery in the 21st century: innovations for novel drug discovery
NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …
pathological conditions have been treated using plant-derived medicines. These medicines …
Strategies to diversify natural products for drug discovery
G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …
microorganisms that play a pivotal role in drug discovery due to their immense structural …
Current strategies for drug discovery through natural products
AL Harvey, RL Clark, SP Mackay… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance to the field: Natural products are the most consistently successful source of drug
leads, both historically and currently. Despite this, the use of natural products in industrial …
leads, both historically and currently. Despite this, the use of natural products in industrial …
Natural products as catalysts for innovation: a pharmaceutical industry perspective
EK Schmitt, CM Moore, P Krastel, F Petersen - Current Opinion in Chemical …, 2011 - Elsevier
Natural products are evolutionarily designed and chemically distinct from most synthetic
library molecules. In addition to their role as drugs, they are successfully used as molecular …
library molecules. In addition to their role as drugs, they are successfully used as molecular …
The landscape of natural product diversity and their pharmacological relevance from a focus on the Dictionary of Natural Products®
Nature is considered a prolific source of diverse biologically active chemotypes. While most
reviews have focused on the characteristics of the chemical backbones of natural products …
reviews have focused on the characteristics of the chemical backbones of natural products …
Paradigm shift in natural product research: traditional medicine inspired approaches
The development of traditional medicine with the perspectives of safety, efficacy and quality
would help not only to preserve the traditional heritage but also to rationalize the use of …
would help not only to preserve the traditional heritage but also to rationalize the use of …
[HTML][HTML] Evolution of plant-made pharmaceuticals
DR Thomas, CA Penney, A Majumder… - International Journal of …, 2011 - mdpi.com
The science and policy of pharmaceuticals produced and/or delivered by plants has evolved
over the past twenty-one years from a backyard remedy to regulated, purified products. After …
over the past twenty-one years from a backyard remedy to regulated, purified products. After …