[HTML][HTML] Natural products and drug discovery: can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight …

HF Ji, XJ Li, HY Zhang - EMBO reports, 2009 - embopress.org
The medicinal use of natural prod-ucts—compounds that are derived from natural sources
such as plants, animals or micro-organisms—precedes recorded human history probably by …

[HTML][HTML] The success of natural products in drug discovery

M Lahlou - 2013 - scirp.org
Drug discovery leading to robust and viable lead candidates' remains a challenging
scientific task, which is the transition from a screening hit to a drug candidate, requires …

[图书][B] Plant-derived natural products

AE Osbourn, V Lanzotti - 2009 - Springer
Plants produce a huge array of natural products (secondary metabolites). These compounds
have important ecological functions, providing protection against attack by herbivores and …

[HTML][HTML] Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Strategies to diversify natural products for drug discovery

G Li, HX Lou - Medicinal research reviews, 2018 - Wiley Online Library
Natural product libraries contain specialized metabolites derived from plants, animals, and
microorganisms that play a pivotal role in drug discovery due to their immense structural …

Current strategies for drug discovery through natural products

AL Harvey, RL Clark, SP Mackay… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance to the field: Natural products are the most consistently successful source of drug
leads, both historically and currently. Despite this, the use of natural products in industrial …

Natural products as catalysts for innovation: a pharmaceutical industry perspective

EK Schmitt, CM Moore, P Krastel, F Petersen - Current Opinion in Chemical …, 2011 - Elsevier
Natural products are evolutionarily designed and chemically distinct from most synthetic
library molecules. In addition to their role as drugs, they are successfully used as molecular …

The landscape of natural product diversity and their pharmacological relevance from a focus on the Dictionary of Natural Products®

F Chassagne, G Cabanac, G Hubert, B David… - Phytochemistry …, 2019 - Springer
Nature is considered a prolific source of diverse biologically active chemotypes. While most
reviews have focused on the characteristics of the chemical backbones of natural products …

Paradigm shift in natural product research: traditional medicine inspired approaches

PK Mukherjee, S Bahadur, RK Harwansh… - Phytochemistry …, 2017 - Springer
The development of traditional medicine with the perspectives of safety, efficacy and quality
would help not only to preserve the traditional heritage but also to rationalize the use of …

[HTML][HTML] Evolution of plant-made pharmaceuticals

DR Thomas, CA Penney, A Majumder… - International Journal of …, 2011 - mdpi.com
The science and policy of pharmaceuticals produced and/or delivered by plants has evolved
over the past twenty-one years from a backyard remedy to regulated, purified products. After …