Current strategies for drug discovery through natural products
AL Harvey, RL Clark, SP Mackay… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance to the field: Natural products are the most consistently successful source of drug
leads, both historically and currently. Despite this, the use of natural products in industrial …
leads, both historically and currently. Despite this, the use of natural products in industrial …
Drug discovery and natural products: end of an era or an endless frontier?
JWH Li, JC Vederas - Science, 2009 - science.org
Historically, the majority of new drugs have been generated from natural products
(secondary metabolites) and from compounds derived from natural products. During the past …
(secondary metabolites) and from compounds derived from natural products. During the past …
Paradigm shift in natural product research: traditional medicine inspired approaches
The development of traditional medicine with the perspectives of safety, efficacy and quality
would help not only to preserve the traditional heritage but also to rationalize the use of …
would help not only to preserve the traditional heritage but also to rationalize the use of …
[HTML][HTML] Herbal medicine: an introduction to its history, usage, regulation, current trends, and research needs
S Wachtel-Galor, IFF Benzie - 2012 - europepmc.org
Plants are rich in a variety of compounds. Many are secondary metabolites and include
aromatic substances, most of which are phenols or their oxygen-substituted derivatives such …
aromatic substances, most of which are phenols or their oxygen-substituted derivatives such …
[图书][B] Phytochemistry: Volume 2: Pharmacognosy, Nanomedicine, and Contemporary Issues
As volume 2 of this three-volume set on phytochemistry, this book features chapters that
comprehensively review a selection of important recent advances in ethnopharmacology …
comprehensively review a selection of important recent advances in ethnopharmacology …
Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine
KC Nicolaou, S Rigol - Natural product reports, 2020 - pubs.rsc.org
Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …
molecules of living Nature in the laboratory, and by extension, their analogues. Although …
Natural products as pharmaceuticals and sources for lead structures
DJ Newman, GM Cragg, DGI Kingston - The practice of medicinal …, 2008 - Elsevier
Publisher Summary Plant-based systems continue to play an essential role in health care,
and their use by different cultures is extensively documented. This chapter reviews the …
and their use by different cultures is extensively documented. This chapter reviews the …
Screening of natural products for drug discovery
M Lahlou - Expert opinion on drug discovery, 2007 - Taylor & Francis
The discovery of new biologically active compounds derived from natural products seems to
be the main objective of many scientific researchers and pharmaceutical companies …
be the main objective of many scientific researchers and pharmaceutical companies …
Natural products to drugs: natural product derived compounds in clinical trials
MS Butler - Natural product reports, 2005 - pubs.rsc.org
Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …
are being evaluated in clinical trials or in registration (current 31 December 2004) have …
The impact of natural products upon modern drug discovery
A Ganesan - Current opinion in chemical biology, 2008 - Elsevier
In the period 1970–2006, a total of 24 unique natural products were discovered that led to
an approved drug. We analyze these successful leads in terms of drug-like properties, and …
an approved drug. We analyze these successful leads in terms of drug-like properties, and …