Current strategies for drug discovery through natural products

AL Harvey, RL Clark, SP Mackay… - Expert opinion on drug …, 2010 - Taylor & Francis
Importance to the field: Natural products are the most consistently successful source of drug
leads, both historically and currently. Despite this, the use of natural products in industrial …

Drug discovery and natural products: end of an era or an endless frontier?

JWH Li, JC Vederas - Science, 2009 - science.org
Historically, the majority of new drugs have been generated from natural products
(secondary metabolites) and from compounds derived from natural products. During the past …

Paradigm shift in natural product research: traditional medicine inspired approaches

PK Mukherjee, S Bahadur, RK Harwansh… - Phytochemistry …, 2017 - Springer
The development of traditional medicine with the perspectives of safety, efficacy and quality
would help not only to preserve the traditional heritage but also to rationalize the use of …

[HTML][HTML] Herbal medicine: an introduction to its history, usage, regulation, current trends, and research needs

S Wachtel-Galor, IFF Benzie - 2012 - europepmc.org
Plants are rich in a variety of compounds. Many are secondary metabolites and include
aromatic substances, most of which are phenols or their oxygen-substituted derivatives such …

[图书][B] Phytochemistry: Volume 2: Pharmacognosy, Nanomedicine, and Contemporary Issues

C Egbuna, S Kumar, JC Ifemeje, JV Kurhekar - 2018 - books.google.com
As volume 2 of this three-volume set on phytochemistry, this book features chapters that
comprehensively review a selection of important recent advances in ethnopharmacology …

Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine

KC Nicolaou, S Rigol - Natural product reports, 2020 - pubs.rsc.org
Covering: 1970 to 2020 By definition total synthesis is the art and science of making the
molecules of living Nature in the laboratory, and by extension, their analogues. Although …

Natural products as pharmaceuticals and sources for lead structures

DJ Newman, GM Cragg, DGI Kingston - The practice of medicinal …, 2008 - Elsevier
Publisher Summary Plant-based systems continue to play an essential role in health care,
and their use by different cultures is extensively documented. This chapter reviews the …

Screening of natural products for drug discovery

M Lahlou - Expert opinion on drug discovery, 2007 - Taylor & Francis
The discovery of new biologically active compounds derived from natural products seems to
be the main objective of many scientific researchers and pharmaceutical companies …

Natural products to drugs: natural product derived compounds in clinical trials

MS Butler - Natural product reports, 2005 - pubs.rsc.org
Covering: 31st December 2004Natural product and natural product-derived compounds that
are being evaluated in clinical trials or in registration (current 31 December 2004) have …

The impact of natural products upon modern drug discovery

A Ganesan - Current opinion in chemical biology, 2008 - Elsevier
In the period 1970–2006, a total of 24 unique natural products were discovered that led to
an approved drug. We analyze these successful leads in terms of drug-like properties, and …