We investigated the effects that mouse interleukin 3 (IL-3), in comparison to mouse IL-2, has
on the generation of cytotoxic effectors capable of killing line 1 tumor cells. These potent …

Conquering immunosuppression in tumor microenvironments is crucial for effective cancer
immunotherapy. It is well known that interleukin (IL)‐6, a pleiotropic cytokine, is produced in …

Abstract An interleukin (IL)-4-containing tumor environment is reported to be beneficial for
immune clearance of tumor cells in vivo; however, the effect of IL-4 on the effector CD8+ T …

Abstract Interleukin (IL)-4 is a crucial cytokine in tumor immunology. In the initial murine
experiments, IL-4 exhibited potent anti-tumor ability. Tumors genetically modified to produce …

The increase of interleukin-4 (IL-4) level in tumor environment and the up-regulation of IL-4
receptor (IL-4R) on tumor cells have been long observed. However, their significance for …

To study the antitumor effect of local production of interleukin-2 (IL-2) from tumor cells, the
poorly immunogenic murine colon cancer cells, colon26, was transfected with murine IL-2 …

The potential of interleukin 7 (IL-7) to induce an antitumor response in vivo was analyzed.
Therefore, the IL-7 gene was expressed in the plasmacytoma cell line J558L. Although the …

We have devised a sensitive means to assess the antitumor effect of cytokines that act via
the mobilization of host-mediated defenses. This assay involves transfecting malignant cells …

We show that interleukin 3 (IL-3) enhances the generation of tumor-specific cytotoxic T
lymphocytes (CTLs) through the stimulation of host antigen-presenting cells (APCs). The …

Abstract Interleukin 12 (IL‐12) is a pleiotropic cytokine with multiple effects on the immune
system. The antitumor effects of locally produced IL‐12 were examined in 2 tumor model …