A toxicogenomics approach to identify new plausible epigenetic mechanisms of ochratoxin a carcinogenicity in rat
M Marin-Kuan, S Nestler, C Verguet… - Toxicological …, 2006 - academic.oup.com
Ochratoxin A (OTA) is a mycotoxin occurring naturally in a wide range of food commodities.
In animals, it has been shown to cause a variety of adverse effects, nephrocarcinogenicity …
In animals, it has been shown to cause a variety of adverse effects, nephrocarcinogenicity …
In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A
L Arbillaga, A Azqueta, JHM van Delft… - Toxicology and Applied …, 2007 - Elsevier
Ochratoxin A (OTA) is a mycotoxin often found in cereals and agricultural products. There is
unequivocal evidence of renal carcinogenicity of OTA in male rats, although the mechanism …
unequivocal evidence of renal carcinogenicity of OTA in male rats, although the mechanism …
Ochratoxin A: potential epigenetic mechanisms of toxicity and carcinogenicity
B Schilter, M Marin-Kuan, T Delatour… - Food additives and …, 2005 - Taylor & Francis
Assessment of the significance to human health of ochratoxin A (OTA) in food is limited by a
lack of human toxicity data. Therefore, OTA risk evaluation relies mainly on the use of animal …
lack of human toxicity data. Therefore, OTA risk evaluation relies mainly on the use of animal …
Ochratoxin A carcinogenicity involves a complex network of epigenetic mechanisms
M Marin-Kuan, C Cavin, T Delatour, B Schilter - Toxicon, 2008 - Elsevier
Ochratoxin A (OTA) is a mycotoxin occurring in a wide range of food products. Because of
the limitation of human epidemiological data, the safety significance of OTA in food has to …
the limitation of human epidemiological data, the safety significance of OTA in food has to …
Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
A Pfohl‐Leszkowicz… - Molecular nutrition & food …, 2007 - Wiley Online Library
Ochratoxin A (OTA) is a ubiquitous mycotoxin produced by fungi of improperly stored food
products. OTA is nephrotoxic and is suspected of being the main etiological agent …
products. OTA is nephrotoxic and is suspected of being the main etiological agent …
Gene expression changes induced by ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration
L Arbillaga, A Vettorazzi, AG Gil, JHM van Delft… - Toxicology and applied …, 2008 - Elsevier
Ochratoxin A (OTA), a naturally occurring mycotoxin, is nephrotoxic in all animal species
tested and is considered a potent renal carcinogen, particularly in male rats. Its mechanism …
tested and is considered a potent renal carcinogen, particularly in male rats. Its mechanism …
An update on direct genotoxicity as a molecular mechanism of ochratoxin a carcinogenicity
A Pfohl-Leszkowicz, RA Manderville - Chemical research in …, 2012 - ACS Publications
Ochratoxin A (OTA) is a naturally occurring chlorophenolic fungal toxin that contaminates a
wide range of food products and poses a cancer threat to humans. The mechanism of action …
wide range of food products and poses a cancer threat to humans. The mechanism of action …
Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle …
D Hibi, A Kijima, K Kuroda, Y Suzuki, Y Ishii… - The Journal of …, 2013 - jstage.jst.go.jp
Ochratoxin A (OTA) is a renal carcinogen primarily affecting the S3 segment of proximal
tubules in rodents. In our previous study, we reported that OTA induces reporter gene …
tubules in rodents. In our previous study, we reported that OTA induces reporter gene …
A New Approach to Studying Ochratoxin A (OTA)-Induced Nephrotoxicity: Expression Profiling in Vivo and in Vitro Employing cDNA Microarrays
A Lühe, H Hildebrand, U Bach… - Toxicological …, 2003 - academic.oup.com
Ochratoxin A (OTA) is a mycotoxin often found in cereals as a contaminant, and it is known
to cause severe nephrotoxicity in animals and humans. There have been several …
to cause severe nephrotoxicity in animals and humans. There have been several …
Ochratoxin A and mitotic disruption: mode of action analysis of renal tumor formation by ochratoxin A
A Mally - Toxicological Sciences, 2012 - academic.oup.com
The mycotoxin and food contaminant ochratoxin A (OTA) is a potent renal carcinogen in
rodents, but its mode of action (MoA) is still poorly defined. In 2006, the European Food …
rodents, but its mode of action (MoA) is still poorly defined. In 2006, the European Food …