Identification of biomarkers of human skin ageing in both genders. Wnt signalling-a label of skin ageing?

E Makrantonaki, TC Brink, V Zampeli, RM Elewa… - PloS one, 2012 - journals.plos.org
The goal of our work has been to investigate the mechanisms of gender-independent
human skin ageing and examine the hypothesis of skin being an adequate model of global …

Genomic-driven insights into changes in aging skin

MK Robinson, RL Binder… - Journal of drugs in …, 2009 - pubmed.ncbi.nlm.nih.gov
Like all tissues, the skin ages due to the passage of time (chronologic aging). However, skin
is also exposed to external insults, such as sunlight. Aging due to chronic sun exposure …

[HTML][HTML] Signatures of photo-aging and intrinsic aging in skin were revealed by transcriptome network analysis

BA Cho, SK Yoo, JS Seo - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
There are various factors that alter physiological characteristics in skin. Elucidating the
underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may …

Skin differences based on age and chronicity of ultraviolet exposure: results from a gene expression profiling study

JA McGrath, MK Robinson… - British Journal of …, 2012 - Wiley Online Library
Background Skin ageing represents an inevitable physiological consequence of getting
older but the impact on personal health and wellbeing can be significant, and therefore …

Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB

DJ Haustead, A Stevenson, V Saxena, F Marriage… - Scientific reports, 2016 - nature.com
Age is well-known to be a significant factor in both disease pathology and response to
treatment, yet the molecular changes that occur with age in humans remain ill-defined. Here …

A systematic review of skin ageing genes: gene pleiotropy and genes on the chromosomal band 16q24. 3 may drive skin ageing

JY Ng, FT Chew - Scientific Reports, 2022 - nature.com
Skin ageing is the result of intrinsic genetic and extrinsic lifestyle factors. However, there is
no consensus on skin ageing phenotypes and ways to quantify them. In this systematic …

Genetic polymorphisms and skin aging: the identification of population genotypic groups holds potential for personalized treatments

J Naval, V Alonso, MA Herranz - Clinical, cosmetic and …, 2014 - Taylor & Francis
Introduction Skin changes are among the most visible signs of aging. Skin properties such
as hydration, elasticity, and antioxidant capacity play a key role in the skin aging process …

The effect of aging in primary human dermal fibroblasts

JC Lago, MB Puzzi - PloS one, 2019 - journals.plos.org
Skin aging is a complex process, and alterations in human skin due to aging have distinct
characteristic as compared to other organs. The aging of dermal cells and the biological …

Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age

AB Kimball, MB Alora-Palli, M Tamura… - Journal of the American …, 2018 - Elsevier
Background Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible
signs of skin aging. Objective We evaluated molecular changes occurring in photoexposed …

[PDF][PDF] Identification of biological processes and potential inhibitors for aging skin

J Wang, H Gu - 2021 - scholar.archive.org
Aging is a critical risk factor for developing many diseases such as skin diseases. Aging skin
is caused by the decline of regenerative potential and function of tissues. Here, we aim to …