Considerable evidence has shown that elevated plasma or cerebrospinal fluid (CSF) urate
levels correlated with a reduced risk of Parkinson's disease (PD). Based on its anti-oxidative …

Background Multiple risk factors contribute to the progression of Parkinson's disease,
including oxidative stress and neuroinflammation. Epidemiological studies have revealed a …

Higher plasma urate level is reported to be associated with a reduced risk and slower
progression of Parkinson's disease (PD). In this study, we explored the effects of urate on …

Background Mounting evidence shows that urate may become a biomarker of Parkinson's
disease (PD) diagnosis and prognosis and a neuroprotectant candidate for PD therapy …

Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in
humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) …

Parkinson's disease (PD) is a progressive neurodegenerative disease with characteristic
motor manifestations. Although appreciation of PD as a multisystem disorder has grown …

Urate is the end product of purine metabolism and a major antioxidant circulating in humans.
Recent data link higher levels of urate with a reduced risk of developing Parkinson's disease …

Urate has emerged as a promising target for neuroprotection based on epidemiological
observations, preclinical models, and early clinical trial results in multiple neurologic …

There is evidence to support that oxidative stress is increased in Parkinson's disease (PD)
and contributes to the degeneration of dopaminergic neurons. Recent research has shown …

Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a
protective effect in neurodegenerative disorders, including Alzheimer's Disease. Genetic …