Animal models have significantly contributed to the understanding of reward-related
behaviors, such as in Substance Use Disorder research. One of the most heavily utilized …

Background The expanding set of genomics tools available for inbred mouse strains has
renewed interest in phenotyping larger sets of strains. The present study aims to explore …

Repeated exposure to drugs of abuse produces forms of experience-dependent plasticity
including behavioral sensitization. Although a single exposure to many addicting …

Alarge body of animal research within the field of drug abuse has established that
environmental variables can significantly modulate a range of addiction-related behaviors …

The present protocol describes the Conditioned Place Preference (CPP) as a model of
relapse in drug addiction. In this model, animals are first trained to acquire a conditioned …

Background: Substance use disorder emerges in a small proportion of drug users and has
the characteristics of a chronic relapsing pathology. Aims: Our study aimed to demonstrate …

Drug reinforcement learning is relevant for the development of addiction. The present study
investigated how changes in the magnitude of drug‐unconditioned stimulus during …

Outbred, male Sprague–Dawley rats can be classified as either low or high cocaine
responders (LCRs or HCRs, respectively) based on cocaine-induced locomotor activity in an …

Rationale Few effective treatments exist for cocaine use disorders due to gaps in knowledge
about its complex etiology. Genetically defined animal models provide a useful tool for …

The conditioned place preference (CPP) procedure is a popular method used for testing the
rewarding properties of human drugs of abuse. Most CPP studies utilize mammalian …