Juvenile systemic lupus erythematosus (JSLE) is a chronic, recurrent multisystem
inflammatory disease, caused by a combination of environmental events and genetic risk …

Background Juvenile systemic lupus erythematosus (JSLE) is a polygenic, autoimmune
disorder of unknown origin. As proinflammatory cytokines, including interleukin-6 (IL-6) and …

Purpose Juvenile systemic lupus erythematosus (JSLE) is a severe and chronic
autoimmune disease of unknown origin. Inflammatory cytokines can play a pivotal role in the …

As abundant types of genetic predisposition and environmental factors seem to be
associated with the development of juvenile-onset systemic lupus erythematosus (JSLE), we …

Interleukin (IL)-10 expression is regulated by its promoter and correlated with the activity of
adult-onset lupus (systemic lupus erythematosus (SLE)). As the pathogenesis of adult-onset …

The purpose of this study was to examine whether several allelic variants in the polymorphic
interleukin (IL)‐10 promoter region were related with an increased risk of developing …

The human interleukin 6 receptor consists of two membrane‐bound glycoproteins (IL‐6 R α,
IL‐6RA and gp130/IL‐6 R β, IL‐6RB) interacting with IL‐6, which is a multifunctional …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Cytokine gene
polymorphisms play an important role in SLE. Thus, this study aimed to investigate the …

The purpose of this study was to determine whether interleukin (IL)‐6 and IL‐8 gene
polymorphisms were markers of susceptibility to or severity of systemic lupus erythematosus …

Identification of susceptibility genes in systemic lupus erythematosus (SLE) has recently
become a topic of interest. The IL-10 promoter contains three single base-pair substitutions …