Background This study aimed to determine the association between circulating leptin levels
and total depressive symptoms as well as depressive symptom dimensions (cognitive and …

Objective Animal models suggest that impaired leptin production, or leptin resistance
despite increased leptin levels, may contribute to depression. The link between leptin and …

Background Evidence for a role of leptin in depression is limited and conflicting.
Inconclusive findings may be explained by the complex effect of obesity on leptin signaling …

Objective: The present study investigated whether peripheral leptin levels are associated
with current depressive episodes in a cross-sectional study nested within a population …

Objective Depression in Type 2 diabetes is associated with obesity, cardiovascular disease,
and mortality. Leptin is a plausible mediating factor because it has been related to obesity …

BACKGROUND: There is conflicting evidence regarding levels of leptin in depression. In this
study we aimed to investigate the relationship between serum leptin level and depression in …

Leptin is thought to be related to vegetative symptoms of depression such as alterations in
food intake and weight. Fifty‐seven drug‐free patients and 26 healthy controls were enrolled …

Background Depression is a seriously disabling public health problem with very high world-
wide prevalence. This study examined cross-sectional association between depression and …

Background Obesity-related dysregulation of leptin signaling (eg, hyperleptinemia due to
central functional resistance) may affect mood. However, evidence for leptin dysregulation in …

Leptin is known to regulate food intake and energy expenditure. Since loss of appetite and
body weight are important signs and symptoms of major depression we studied leptin …