The last few years have seen major advances in common non-syndromic obesity research,
much of it the result of genetic studies. This Review outlines the competing hypotheses …

The prevalence of obesity and diabetes, which are heritable traits that arise from the
interactions of multiple genes and lifestyle factors, continues to rise worldwide, causing …

Understanding of the genetic influences on obesity has increased at a tremendous rate in
recent years. By some estimates, 40 to 70 percent of the variation in obesity-related …

Obesity is a multifactorial trait with evidence of a genetic component. Obesity is very
common in all westernized countries, including Finland, where 10% of the adult population …

The prevalence of obesity has nearly doubled worldwide over the past three decades, but
substantial differences exist between nations. Although these differences are partly due to …

Although several genomewide scans have identified quantitative-trait loci influencing
several obesity-related traits in humans, genes influencing normal variation in obesity …

There are about 250 million adults who are obese and at least 500 million who are
overweight in the world at the moment (1). Given these numbers, it is not surprising that the …

Excess body fat or body mass relative to height aggregates in families. It is commonly
recognized that this familial aggregation of human obesity is accounted for in part by a …

Chromosomal synteny between the mouse model and humans was used to map a gene for
the complex trait of obesity. Analysis of NZB/BINJ x SM/J intercross mice located a …

Obesity is a major public health problem with strong genetic determination. Multiple genetic
variants have been implicated for obesity by conducting genome-wide association (GWA) …