Structure and Regulation of Voltage-Gated Ca2+ Channels

WA Catterall - Annual review of cell and developmental biology, 2000 - annualreviews.org
▪ Abstract Voltage-gated Ca2+ channels mediate Ca2+ entry into cells in response to
membrane depolarization. Electrophysiological studies reveal different Ca2+ currents …

Molecular cloning and functional expression of Cav3.1c, a T‐type calcium channel from human brain

LL Cribbs, JC Gomora, AN Daud, JH Lee… - FEBS …, 2000 - Wiley Online Library
Low voltage‐activated T‐type calcium channels are encoded by a family of at least three
genes, with additional diversity created by alternative splicing. This study describes the …

Ca2+-and voltage-dependent inactivation of the expressed L-type Cav1. 2 calcium channel

F Hofmann - Archives of biochemistry and biophysics, 2005 - Elsevier
Ca2+-dependent regulation of the ion current through the α1Cβ2aα2δ-1 (L-type) calcium
channel transiently expressed in HEK 293 cells was investigated using whole cell patch …

Identification of the T-Type Calcium Channel (CaV3.1d) in Developing Mouse Heart

LL Cribbs, BL Martin, EA Schroder, BB Keller… - Circulation …, 2001 - Am Heart Assoc
During cardiac development, there is a reciprocal relationship between cardiac
morphogenesis and force production (contractility). In the early embryonic myocardium, the …

Auxiliary subunits: essential components of the voltage-gated calcium channel complex

J Arikkath, KP Campbell - Current opinion in neurobiology, 2003 - Elsevier
Voltage-gated calcium channels are important mediators of several physiological processes,
including neuronal excitability and muscle contraction. At the molecular level, the channels …

Neuronal voltage-gated calcium channels: brief overview of their function and clinical implications in neurology

EE Benarroch - Neurology, 2010 - AAN Enterprises
Voltage-gated calcium (Ca2) channels are a major source of Ca2 influx and have a critical
role in Ca2 signaling in all cells. The nervous system expresses a number of different types …

β subunits of voltage-gated calcium channels

AC Dolphin - Journal of bioenergetics and biomembranes, 2003 - Springer
Calcium channel β subunits have marked effects on the trafficking and on several of the
biophysical properties of all high voltage activated calcium channels. In this article I shall …

[HTML][HTML] L-type voltage-gated calcium channels: understanding function through structure

MC Wang, A Dolphin, A Kitmitto - FEBS letters, 2004 - Elsevier
L-type voltage-gated calcium channels (VGCCs) are multisubunit membrane proteins that
regulate calcium influx into excitable cells. Within the last two years there have been four …

Identification of a T-Type Ca2+ Channel Isoform in Murine Atrial Myocytes (AT-1 Cells)

J Satin, LL Cribbs - Circulation research, 2000 - Am Heart Assoc
Calcium channels are important targets for therapeutics, but their molecular diversity
complicates characterization of these channels in native heart cells. In this study, we identify …

Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family

JH Lee, AN Daud, LL Cribbs, AE Lacerda… - Journal of …, 1999 - Soc Neuroscience
Low voltage-activated Ca2+ channels play important roles in pacing neuronal firing and
producing network oscillations, such as those that occur during sleep and epilepsy. Here we …