Synthesis of new chrysin derivatives with substantial antibiofilm activity

S Bhowmik, P Anand, R Das, T Sen, Y Akhter… - Molecular Diversity, 2021 - Springer
Multidrug resistance mechanism of microorganisms towards conventional antimicrobials
nowadays faces a common health problem. So, searching and development of new …

[PDF][PDF] Synthesis of Some New Chrysin Derivatives and Their Biological Assessment as Antibacterial, Antibiofilm and Antifungal Agent.

S Bhowmik, T Das, S Ghosh, BK Sharma… - Asian Journal of …, 2018 - academia.edu
Some new derivatives of natural chrysin have been synthesized and evaluated for
antibacterial, antibiofilm and antifungal activities. Three compounds, namely 2a, 2e, 2i …

Synthesis, characterization and molecular docking studies of novel 2-amino 3-cyano pyrano[2,3H]chrysin derivatives as potential antimicrobial agents

P Ramesh, CS Reddy, K Suresh Babu… - Medicinal Chemistry …, 2015 - Springer
A series of novel 2-amino 3-cyano 4-aryl pyrano [2, 3 H] chrysin derivatives (3a–m) were
efficiently synthesized by one-pot three-component reaction of aromatic aldehydes …

Facile synthesis and biological evaluation of chrysin derivatives

N Omonga, Z Zia, H Ghanbour… - Journal of Chemical …, 2021 - journals.sagepub.com
In this paper, novel synthetic methods, including microwave O-alkylation, were used to
produce several chrysin derivatives. These compounds were purified, characterised and …

Xanthone synthetic derivatives with high anticandidal activity and positive mycostatic selectivity index values

K Rząd, R Ioannidi, P Marakos, N Pouli, M Olszewski… - Scientific Reports, 2023 - nature.com
With the current massive increases in drug-resistant microbial infection as well as the
significant role of fungal infections in the death toll of COVID-19, discovering new antifungals …

Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents

KS Babu, TH Babu, PV Srinivas, KH Kishore… - Bioorganic & medicinal …, 2006 - Elsevier
The natural product, chrysin (5, 7-dihydroxy flavone), obtained from Oroxylum indicum,
exhibits numerous biological activities including anticancer, anti-inflammatory, and …

Click-based synthesis of bromotyrosine alkaloid analogs as potential anti-biofilm leads for SAR studies

S Andjouh, Y Blache - Bioorganic & Medicinal Chemistry Letters, 2015 - Elsevier
A library of triazole-based analogs of bromotyramine alkaloids such as verongamines,
hemibastadins, pseudoceramine D and clavatidine E was designed in order to identify …

Antimicrobial activity and docking study of synthesized xanthen-3-on derivatives

E Veljović, S Spirtovic-Halilovic… - Research Journal of …, 2018 - cer.ihtm.bg.ac.rs
Twelve previously synthesized biologically active 2, 6, 7-trihydroxy-9-aryl-3H-xanthen-3-one
derivatives (1-12) were evaluated in vitro for their antimicrobial activity against four bacteria …

In‐house chemical library repurposing: A case example for Pseudomonas aeruginosa antibiofilm activity and quorum sensing inhibition

L Ravithej Singh, VC Tripathi, S Raj… - Drug Development …, 2018 - Wiley Online Library
Abstract Hit, Lead & Candidate Discovery Drug repurposing has become a recent trend in
drug development programs, where previously developed drugs are explored for hit and …

Chromene-dihydropyrimidinone and xanthene-dihydropyrimidinone hybrids: design, synthesis, and antibacterial and antibiofilm activities

SJ Santos, FCP Rossatto, NS Jardim, DS Ávila… - New Journal of …, 2023 - pubs.rsc.org
A series of eleven chromene-dihydropyrimidinone and eleven xanthene-
dihydropyrimidinone hybrid compounds were easily synthesized through a sequential …