[HTML][HTML] Dexmedetomidine exerts an anti-inflammatory effect via α2 adrenoceptors to alleviate cognitive dysfunction in 5xFAD mice
S Luo, L Li, L Guo, L Wang, Y Wang, N Chen… - Frontiers in Aging …, 2022 - frontiersin.org
Background: Inflammation promotes the progression of Alzheimer's disease (AD). In this
study, we explored the effect of dexmedetomidine on inflammation and cognitive function in …
study, we explored the effect of dexmedetomidine on inflammation and cognitive function in …
Dexmedetomidine mitigates neuroinflammation in an Alzheimer's disease mouse model via the miR-204-3p/FBXL7 signaling axis
X Lian, X Zhang, W Chen, F Xue, G Wang - Brain Research, 2024 - Elsevier
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by
neuroinflammation. Dexmedetomidine (Dex) is known for its neuroprotective properties in …
neuroinflammation. Dexmedetomidine (Dex) is known for its neuroprotective properties in …
Resolving neuroinflammatory and social deficits in ASD model mice: Dexmedetomidine downregulates NF-κB/IL-6 pathway via α2AR
ZK Liang, W Xiong, C Wang, L Chen, X Zou… - Brain, Behavior, and …, 2024 - Elsevier
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that severely affects
individuals' daily life and social development. Unfortunately, there are currently no effective …
individuals' daily life and social development. Unfortunately, there are currently no effective …
[HTML][HTML] The effects of dexmedetomidine on the cognitive function of mild cognitive impairment (MCI) rats
Q Zhou, D Xie, T Chen, Y Gao, L Lin… - Annals of Translational …, 2022 - ncbi.nlm.nih.gov
Background The study sought to investigate the effects of dexmedetomidine (DEX) on
cognitive function after anesthesia and to examine its actual mechanism. Methods A total of …
cognitive function after anesthesia and to examine its actual mechanism. Methods A total of …
Dexmedetomidine attenuates the neuroinflammation and cognitive dysfunction in aged mice by targeting the SNHG14/miR‑340/NF‑κB axis
G He, H Ni, K Wang, H Gao, Y Li, J Gu… - Biomedical …, 2023 - spandidos-publications.com
Neuroinflammation plays a key role in the pathogenesis of postoperative cognitive
dysfunction (POCD). Results of our previous study demonstrated that dexmedetomidine …
dysfunction (POCD). Results of our previous study demonstrated that dexmedetomidine …
Dexmedetomidine protects aged rats from postoperative cognitive dysfunction by alleviating hippocampal inflammation
N Chen, X Chen, J Xie, C Wu… - Molecular Medicine …, 2019 - spandidos-publications.com
The present study investigated the effect of dexmedetomidine on hippocampal inflammation
and cognitive function in rats with postoperative cognitive dysfunction (POCD). A total of 80 …
and cognitive function in rats with postoperative cognitive dysfunction (POCD). A total of 80 …
Dexmedetomidine ameliorates postoperative cognitive dysfunction in aged mice
X Xie, Z Shen, C Hu, K Zhang, M Guo, F Wang… - Neurochemical …, 2021 - Springer
Neuroinflammation and oxidative stress coexist and interact in the progression of
postoperative cognitive dysfunction (POCD) and other neurodegenerative disease …
postoperative cognitive dysfunction (POCD) and other neurodegenerative disease …
DMTHB ameliorates memory impairment in Alzheimer's disease mice through regulation of neuroinflammation
Y Zhang, D Liu, X Yao, J Wen, Y Wang, Y Zhang - Neuroscience Letters, 2022 - Elsevier
Background Alzheimer's disease (AD) is one of the most prevalent neurodegenerative
diseases. Growing evidence suggested that AD is associated with neuroinflammation …
diseases. Growing evidence suggested that AD is associated with neuroinflammation …
Cepharanthine promotes the effect of dexmedetomidine on the deposition of β-amyloid in the old age of the senile dementia rat model by regulating inflammasome …
Y Wu, Y Cao, S Wang, X Xu, M Wang - Folia Neuropathologica, 2019 - termedia.pl
Results Data of the study reveal that cepharanthine alone and in combination with
dexmedetomidine improves the neurological function score and cognitive function in SD …
dexmedetomidine improves the neurological function score and cognitive function in SD …
Dimethyl itaconate reduces cognitive impairment and neuroinflammation in Appswe/Ps1δe9 transgenic mouse model of alzheimer's disease
J Xiong, DL Lu, BQ Chen, TY Liu, ZX Wang - NeuroMolecular Medicine, 2023 - Springer
Alzheimer's disease (AD) is the most common type of dementia characterized by abnormal
accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and neuronal loss. Dimethyl …
accumulation of amyloid-β (Aβ) plaques, neuroinflammation, and neuronal loss. Dimethyl …