The Gi/o-coupled histamine H4 receptor is highly expressed in hemopoietic cells and is a
promising new target for the treatment of chronic inflammatory diseases. 1-[(5-Chloro-1 H …

Desensitization is a major mechanism to regulate the functional response of G protein-
coupled receptors. In this work we studied whether the human histamine H 3 receptor of 445 …

In an integrative approach, we studied the role of histamine H2 receptors in the mouse heart.
We noted that histamine, added cumulatively to the organ bath, failed to affect the force of …

Histamine H2 receptor expression was studied in adult and developing rat brain. Northern
blot and in situ hybridizations indicated that histamine H2 receptor messenger RNA …

Existing data on the expression of H4 histamine receptor in the CNS are conflicting and
inconclusive. In this report, we present the results of experiments that were conducted in …

In this article, we review the recent developments in the field of histamine research. Besides
the description of pharmacological tools for the H1, H2 and H3 receptor, specific attention is …

The G i/o protein-coupled histamine H 3 receptor is distributed throughout the central
nervous system including areas like cerebral cortex, hippocampus and striatum with the …

Histaminergic H3 receptors modulate the release of neurotransmitters within the CNS and
periphery. Ligands for these receptors have potential clinical utility in a variety of disease …

In this article, we pharmacologically characterized two naturally occurring human histamine
H3 receptor (hH3R) isoforms, hH3R (445) and hH3R (365). These abundantly expressed …

The recently identified histamine H 4 receptor has revealed a potential new complexity for
the role of histamine in the immune system. To begin to understand the role of this receptor …