BACKGROUND AND PURPOSE The histamine H3 receptor was identified as the
autoreceptor of brain histaminergic neurons. After its cloning, functional H3 receptor …

GT-2227 (4-(6-cyclohexylhex-cis-3-enyl) imidazole) and GT-2331 ((1R, 2R)-4-(2-(5, 5-
dimethylhex-1-ynyl) cyclopropyl) imidazole) were developed as new potent histamine H3 …

The human histamine receptors hH 1 R and hH 2 R constitute important drug targets, and
hH 3 R and hH 4 R have substantial potential in this area. Considering the species …

The histamine H4 receptor (H4R) activates Gαi-mediated signaling and recruits β-arrestin2
upon stimulation with histamine. β-Arrestins play a regulatory role in G protein-coupled …

1 The human H1 receptor gene expressed in Chinese hamster ovary cells (CHOhumH1)
encodes a classical histamine H1 receptor with a pharmacology similar to that of the …

Abstract Effects of histamine receptor ligands on the glibenclamide-sensitive K+ currents
induced by K+ channel openers, cromakalim and Y-26763, were examined in follicle …

The human histamine H4 receptor (H4R), the most recently discovered histamine receptor,
is predominantly expressed on inflammatory cells and lymphoid tissues and characterized …

A set of histamine H 1 receptor (H 1 R) agonists and antagonists was characterized in
functional assays, using dynamic mass redistribution (DMR), electric cell-substrate …

1 Intracellular recordings were made in intact and acutely dissociated vagal afferent
neurones (nodose ganglion cells) of the ferret to investigate the membrane effects of …

Through interaction with G protein‐coupled receptors, histamine regulates pre‐and post‐
synaptically a number of brain functions such as wakefulness, locomotor activity, autonomic …