Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred
to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro …

A cDNA encoding a guinea pig histamine H1 receptor was stably expressed in Chinese
hamster ovary (CHO) cells. In one resulting clone, named CHO (H1), the H1 receptor was …

Histamine H3 receptors were first described in the eighties but finally cloned four years ago.
They are G-protein coupled, mostly presynaptic, and are involved in the control of the …

Increasing evidence supports a role for HA as a neurotransmitter and neuromodulator in
various brain functions, including emotion, cognition, and feeding. The recent cloning of the …

The neurotransmitter histamine exerts its action through four distinct histamine receptors.
The histamine H1 and H2 receptor are well established drug targets, whereas the histamine …

There is ample pharmacological and physiological evidence for yet unidentified histamine
receptors in mammalian brain that are linked to a Cl− conductance. In invertebrates, two …

H3 autoreceptors provide feedback control of neurotransmitter synthesis in histaminergic
neurons, but the transduction pathways involved are poorly understood. In rat brain cortical …

Histamine (HA) is an important neuro-modulator, contributing to a variety of physiological
responses in the mammalian central nervous system (CNS). However there is little …

Starting from the sequence of the human histamine H3 receptor (hH3R) cDNA, we have
cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall …

Histamine-releasing neurons are located exclusively in the TM of the hypothalamus, from
where they project to practically all brain regions, with ventral areas (hypothalamus, basal …